Ultrasound method for revascularization and drug delivery

• US 6,508,783 B2
• Filed: 03/14/2001
• Issued: 01/21/2003
• Est. Priority Date: 03/14/2001
• Status: Expired due to Fees

• Current Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Original Assignee: Scimed Life Systems Incorporated (Boston Scientific Corporation)
• Inventors: DeVore, Lauri J.
• Primary Examiner(s): Ganey, Steven J.
• Application Number:
  US09/808,624
• Publication Number:
  US 20020133101A1
• Time in Patent Office: 678 Days
• Field of Search: 604/19-22, 607/115, 607/119, 607/120, 607/122
• US Class Current: 604/22
• CPC Class Codes: A61B 2017/00247 Making holes in the wall of the heart, e.g. laser Myocardial revascularization
• CPC Class Codes: A61B 2018/00392 Transmyocardial revascularisation
• CPC Class Codes: A61M 2025/0089 Single injection needle protruding axially, i.e. along the longitudinal axis of the catheter, from the distal tip
• CPC Class Codes: A61M 2205/058 with ultrasound therapy
• CPC Class Codes: A61M 2210/125 Heart
• CPC Class Codes: A61M 25/0084 being one or more injection needles
• CPC Class Codes: A61M 37/0092 using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092

Abstract

A method and device for improving blood circulation to an area of interest within a patient'"'"' heart is described. The method comprises inserting a guidable elongated flexible ultrasound device into a patient'"'"'s vasculature, applying ultrasonic energy to an area in need of improved circulation, and injecting materials such as angiogenic materials or contrasting agents into the area of interest. The device, suitable for performing the method, comprises an elongated tubular body, a distal head of the elongated tubular body for introducing ultrasonic energy to an area of interest, and a needle to deliver materials to an area of interest.

Claims

1. A method for improving blood circulation to an area of interest in a heart muscle of a patient, said method comprising the steps of:

inserting a guidable elongated flexible ultrasound device into said patient'"'"'s vasculature, said guidable elongated flexible ultrasound device having an elongate lumen, a distal end, a proximal end, a distal head mounted on said distal end, and a needle mounted to said elongated tubular flexible ultrasound device in fluid communication with said elongate lumen;

guiding said distal head to said area of interest in said heart muscle;

applying ultrasonic energy via said distal head to said area of interest to form a thrombus without removing any heart material from the area of interest; and

injecting a material into said thrombus with said needle.

2. The method of claim 1, wherein said material is an angiogenic material.

3. The method of claim 1, wherein said material is a contrasting agent.

4. The method of claim 1, wherein the step of applying said ultrasonic energy further comprises the step of massaging said area of interest without removing any portion of said heart muscle at said area of interest.

5. The method of claim 1, wherein said needle is attached adjacent to said distal head.

6. The method of claim 1, wherein said needle extends from said distal head.

7. The method of claim 1, wherein the step of inserting said guidable elongated flexible ultrasound device further comprises the step of inserting a guidewire into said patient'"'"'s vasculature and passing said guidable elongated flexible ultrasound device over said guidewire.

8. The method of claim 1, wherein said guidable elongated flexible ultrasound device includes an endoscopic visualization device for visualizing said area of interest.

9. A method for improving blood circulation to an external area of interest in a heart muscle of a patient, said method comprising the steps of:

providing a guidable elongated flexible ultrasound device into said patient'"'"'s chest cavity, said guidable elongated flexible ultrasound device having an elongate lumen, a distal end, a proximal end, a distal head mounted on said distal end, and a needle with a lumen mounted to said elongated tubular flexible ultrasound device in fluid communication with said elongate lumen;

guiding said distal head within said patient'"'"'s chest cavity to contact said exterior area of interest of said heart muscle;

applying ultrasonic energy via said distal head to said external area of interest to form a thrombus without removing any heart material from the area of interest; and

injecting a material into said thrombus with said needle.

10. The method of claim 9, wherein said material is an angiogenic material.

11. The method of claim 9, wherein said material is a contrasting agent.

12. The method of claim 9, wherein the step of applying said ultrasonic energy further comprises the step of massaging said external area of interest without removing any portion of said heart muscle at said external area of interest.

13. The method of claim 9, wherein said needle is attached adjacent to said distal head.

14. The method of claim 9, wherein said needle extends from said distal head.