Medical instrument working end creating very high pressure gradients

• US 6,508,816 B2
• Filed: 02/12/2001
• Issued: 01/21/2003
• Est. Priority Date: 03/27/1998
• Status: Expired due to Term

• Current Assignee: Tsunami MedTech, LLC
• Original Assignee: John H. Shadduck
• Inventors: Shadduck, John H.
• Primary Examiner(s): Dvorak, Linda C. M.
• Assistant Examiner(s): Ruddy, David M.
• Application Number:
  US09/782,649
• Publication Number:
  US 20010037106A1
• Time in Patent Office: 708 Days
• Field of Search: 601/2-3, 606/38, 606/41-50, 606/159, 606/32, 606/34, 607/101
• US Class Current: 606/34
• CPC Class Codes: A61B 18/042 using additional gas becoming plasma
• CPC Class Codes: A61B 18/148 having a short, rigid shaft for accessing the inner body transcutaneously, e.g. for neurosurgery or arthroscopy
• CPC Class Codes: A61B 18/1492 having a flexible, catheter-like structure, e.g. for heart ablation A61B18/1477 takes precedence
• CPC Class Codes: A61B 2018/0041 Removal of thrombosis
• CPC Class Codes: A61B 2018/1213 creating an arc
• CPC Class Codes: A61B 2218/002 Irrigation

Abstract

A micro-catheter system utilizing a microjoule pulsed electrical discharge between first and second electrodes in a recessed lumen at the catheter working end for creating a cavitating volume of electrolytic fluid composition including a pharmacologic agent. The expansion and collapse of media at a high repetition rate creates acoustic waves that propagate distally from the working end of the micro-catheter to disrupt thrombus. The expansion and collapse of such cavitation bubbles “jet” the pharmacologic agent at a controlled velocity into the acoustically-disrupted thrombus to further depolymerize the thrombus. The catheter system includes a computer-controller for independent modulation of (i) all aspects of pharmacologic agent delivery, and (ii) all parameters of electrical discharge to “tailor” the combined acoustic wave effects and pharmacologic agent effects to dissolve thrombus rapidly and efficiently.

Claims

1. A method for applying energy to endovascular media, comprising the steps of:

(a) providing apparatus comprising an electrical discharge source and a catheter having a working surface with a longitudinal open-ended channel therein that carries first and second spaced apart interior electrodes, the first and second electrodes coupled to the electrical discharge source;

(b) introducing the working surface of the catheter to a position proximate the targeted media;

(c) introducing a fluid having a specified electrical resistivity to the channel, thereby defining an interface of the working surface and the targeted media; and

(d) establishing an intense electrical field across the fluid between the first and second electrodes thereby vaporizing the fluid to cause delivery of energy across the interface to the targeted media.

2. The method of claim 1 wherein steps (c) and (d) are repeated at repetition rate ranging from 1 Hz to 1 kHz.

3. The method of claim 1 wherein the vaporization creates pressure gradients that project the fluid in high velocity flows from the working surface.

4. The method of claim 3 wherein the fluid carries a pharmacological agent that is projected into the targeted media.

5. The method of claim 3 wherein the projected fluid is elevated in temperature thereby delivering thermal energy to the targeted media.

6. The method of claim 3 wherein the projected fluid carries a pharmacological agent thereby delivering chemical energy to the targeted media.

7. The method of claim 3 wherein the pressure gradient delivers acoustic energy to the targeted media.

8. A medical instrument for application of energy to body structure of a patient, comprising:

an instrument having a proximal handle end and a working end for positioning proximate to a targeted body structure thereby defining an energy-delivery interface between the working end and the body structure;

at least one bore in the working end terminating in a media entrance port in a working end surface, a proximal portion of the at least one bore fluidly coupled to a remote fluid media inflow source; and

a thermal energy emitter carried at an interior portion of the at least one bore for causing vaporization of fluid media within the at least one bore to thereby cause high pressure gradients within the at least one bore to project high velocity flows of fluid media artifacts across the energy-delivery interface into the body structure.

9. The instrument of claim 8 further comprising a remote energy source and controller that delivers energy in intervals for causing the high pressure gradients.

10. The instrument of claim 9 wherein the energy delivery intervals range from about 1 Hz to 1 kHz.

11. The instrument of claim 8 wherein thermal energy emitter comprises at least one electrode coupled to an electrical source.

12. The instrument of claim 8 wherein thermal energy emitter comprises the terminal end of a light channel coupled to a light source.

13. The instrument of claim 8 wherein the artifact comprises a pharmacological agent.

14. The instrument of claim 8 wherein the artifact comprises an electrically resistive or sensative composition.

15. The instrument of claim 8 wherein the artifact comprises a chromophore.

16. A medical instrument for application of energy to a surface of structure with a patient'"'"'s body, comprising:

an instrument having a proximal handle end and a working end for positioning proximate to a targeted body structure thereby defining an energy-delivery interface between the working end and the body structure;

a channel in the working end fluidly coupled to a remote fluid media inflow source;

a thermal energy emitter carried at an interior portion of the channel coupled to a remote energy source; and

an energy source and controller that delivers energy pulses to the emitter having a selected fluence, pulse duration and repetition rate that vaporizes fluid media proximate to the emitter thereby creating very high fluid pressures in the channel to cause high velocity projection of fluid media artifacts from the working end into the body structure.

17. The instrument of claim 16 wherein thermal energy emitter comprises at least one electrode coupled to an electrical source.

18. The instrument of claim 16 wherein thermal energy emitter comprises the terminal end of a light channel coupled to a light source.

19. The instrument of claim 18 wherein the light source emits a wavelength ranging between about 100 nanometers and 3.0 micrometers.

20. A method for applying energy to a targeted structure of a patient'"'"'s body, comprising the steps of:

providing apparatus comprising a thermal energy emitter in the interior of an open-ended channel in an instrument working end surface, the emitter coupled to a remote energy source and controller;

introducing the working end surface of the apparatus to a position proximate the targeted structure;

introducing a fluid having a specified heat capacity into the open-ended channel, thereby defining an interface of the working end surface and the targeted structure; and

delivering energy pulses having a selected fluence, duration and repetition rate to fluid media captured proximate to the emitter to vaporize the fluid thereby creating fluid pressures in the channel that project fluid media artifacts across the interface carried by high velocity fluid media flows from the working end surface.

21. The method of claim 20 further comprising delivering the energy pulses at a specified rate.

22. The method of claim 20 wherein the artifacts carried by the fluid media flows comprises a pharmacological agent.

23. The method of claim 20 wherein the high velocity fluid media flow is elevated in temperature thereby applying thermal energy to the targeted structure.