Transmyocardial revascularization using ultrasound

• US 6,511,444 B2
• Filed: 01/31/2000
• Issued: 01/28/2003
• Est. Priority Date: 02/17/1998
• Status: Expired due to Term

• Current Assignee: Brigham and Women's Hospital Incorporated
• Original Assignee: Brigham and Women's Hospital Incorporated
• Inventors: Fjield, Todd, Daum, Douglas R., Buchanan, Mark T., Hynynen, Kullervo
• Primary Examiner(s): Lateef, Marvin M.
• Assistant Examiner(s): MANTIS MERCADER, ELENI M
• Application Number:
  US09/523,989
• Publication Number:
  US 20020151777A1
• Time in Patent Office: 1,093 Days
• Field of Search: 600/439, 601/2, 601/3, 601/4, 604/22
• US Class Current: 601/2
• CPC Class Codes: A61B 17/22004 using mechanical vibrations, e.g. ultrasonic shock waves A61B17/225 takes precedence
• CPC Class Codes: A61B 2017/00247 Making holes in the wall of the heart, e.g. laser Myocardial revascularization
• CPC Class Codes: A61B 2018/00392 Transmyocardial revascularisation
• CPC Class Codes: A61B 2018/00642 with feedback, i.e. closed loop control

Abstract

A method and apparatus for performing transmyocardial revascularization using ultrasound is disclosed. The apparatus includes a phased array ultrasonic device that includes a plurality of ultrasonic transducer elements which are controlled using a feedback control system so that each ultrasonic transducer element produces an ultrasonic wave of particular power and phase in order to achieve constructive interference at a desired acoustic focus. The constructive interference creates high pressure amplitudes for vaporizing the target tissue at the focus. A method is provided for vaporizing target tissue for which a plurality of ultrasonic transducers are focused so as to provide constructive interference within the target tissue. The ultrasonic beams are launched and produce a rapid rise in tissue temperature that will vaporize the target tissue within the focal zone.

Claims

1. An ultrasonic system for selectively and non-invasively vaporizing body tissue, the system comprising:

an extracorporeal array of ultrasonic transducers, each of said transducers being capable of producing an ultrasonic wave; and

a plurality of channel driving systems, each of said channel driving systems being coupled to one of said transducers and providing an output signal having an amplitude and a phase to a corresponding one of said transducers, each of said channel driving systems including at least one of a power measurement system and a phase detector for providing measured values of a respective one of said amplitude and said phase of said output signal, each of said channel driving systems adjusting said corresponding output signal based on a pre-selected value of said output signal and the measured value of said output signal to selectively vaporize said body tissue.

2. The ultrasonic system of claim 1, further comprising a control system operatively coupled to each of said channel driving systems, said control system providing selected values for at least one of said amplitude and said phase of said output signal of each of said channel driving systems.

3. The ultrasonic system of claim 2, wherein said control system provides selected values for said amplitude and said phase of said output signal of each of said channel driving systems.

4. The ultrasonic system of claim 1, wherein each channel driving system of said plurality of channel driving systems includes a power measurement system and a phase detector.

5. The ultrasonic system of claim 1, wherein each of said channel driving systems comprises a power converter having a switching amplifier, said power converter producing an AC signal.

6. The ultrasonic system of claim 5, wherein said switching amplifier is a class D/E amplifier.

7. The ultrasonic system of claim 5, wherein each of said channel driving systems further comprises a harmonic filter, said power converter and said harmonic filter producing a substantially single frequency sinusoidal output signal.

8. The ultrasonic system of claim 1, wherein each of said channel driving systems comprises a power regulator operatively coupled to said power measurement system, said power regulator adjusting the amplitude of said output signal based on said pre-selected value of said output signal and the measured amplitude of said output signal.

9. The ultrasonic system of claim 1, wherein each of said channel driving systems further comprises a phase shifter operatively coupled to said phase detector, said phase shifter adjusting the phase of said output signal based on said pre-selected value of output signal and the measured phase of said output signal.

10. The ultrasonic system of claim 1, wherein each of said transducers includes matching circuitry to provide an impedance match between the corresponding channel driving system and the corresponding transducer.

11. An ultrasonic system for selectively and non-invasively vaporizing body tissue, the system comprising:

an extracorporeal array of ultrasonic transducer elements, each of said transducer elements being capable of producing an ultrasonic wave;

a plurality of channel driving systems, each of said channel driving systems being coupled to one of said transducer elements and providing an output signal having an amplitude and a phase to said one of said transducer elements; and

a control system operatively coupled to each of said channel driving systems, said control system providing a selected value of said phase of said output signal of each of said channel driving systems;

each of said channel driving systems including a phase detector for providing measured value of said phase of said corresponding output signal or of said phase of said corresponding ultrasonic wave, each of said channel driving systems adjusting said corresponding output signal based on said selected value of said phase of said output signal and the measured value of said phase of said output signal or said ultrasonic wave to selectively vaporize said body tissue.

12. The ultrasonic system of claim 11, wherein each of said channel driving systems further includes an amplitude measurement system for measuring the amplitude of said corresponding output signal, and

wherein said control system provides a selected value of the amplitude of said output signal of each of said channel driving systems, each of said channel driving systems adjusting said corresponding output signal based on said selected value of the amplitude of said output signal and the measured value of the amplitude of said output signal.

13. A method of selectively and non-invasively vaporizing human tissue, the method comprising the steps of:

providing an ultrasonic system comprising an extracorporeal array of channel driver and ultrasonic transducer pairs for producing an array of ultrasonic waves,

launching the array of ultrasonic waves at a target tissue site within the body, and

focusing the ultrasonic waves at the target site by producing constructive interference of the ultrasonic waves at the target site, said focusing resulting in vaporization of tissue at the target site, said focusing including

measuring a value of at least one of signal amplitude and phase transmitted to the array of ultrasonic transducers, and

adjusting at least one of the amplitude and the phase transmitted to the array of ultrasonic transducers based on the measured value and a corresponding pre-selected value.

14. The method of claim 13, wherein said step of focusing comprises

measuring the value of the signal amplitude and the phase transmitted to the array of ultrasonic transducers, and

adjusting the amplitude and the phase transmitted to the array of ultrasonic transducers based on the measured value and a corresponding pre-selected value of the amplitude or phase.

15. The method of claim 13, wherein said step of focusing comprises

measuring a value of at least one of signal amplitude and phase trasmitted to each of the ultrasonic transducers, and

adjusting at least one of the amplitude and the phase transmitted to each of the ultrasonic transducers based on the measured value and a corresponding preselected value.

16. The method of claim 13, further comprising the steps of selecting values of signal power and of phase for the array of ultrasonic transducers and transmitting the values to the array of ultrasonic transducers.

17. A method of selectively and non-invasively vaporizing human tissue, the method comprising the steps of:

providing an ultrasonic system comprising an extracorporeal array of channel driver and ultrasonic transducer pairs for producing an array of ultrasonic waves,

launching the array of ultrasonic waves at a target tissue site within the body, and

focusing the ultrasonic waves at the target site by producing constructive interference of the ultrasonic waves at the target site, said focusing resulting in vaporization of tissue at the target site, said focusing including

measuring a value of signal phase transmitted to the array of ultrasonic transducers or a value of the phase of the ultrasonic waves, and

adjusting signal phase transmitted to the array of ultrasonic transducers based on one of the measured values and a corresponding pre-selected value.

18. The method of claim 17, wherein said step of focusing includes

measuring the value of the signal amplitude transmitted to the array of ultrasonic transducers, and

adjusting the amplitude transmitted to the array of ultrasonic transducers based on the measured value of the signal amplitude and a corresponding pre-selected value of the signal amplitude.