Tri- and tetra-valent monospecific antigen-binding proteins
First Claim
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1. A tri- or tetra-valent monospecific antigen-binding protein comprising three or four Fab fragments bound to each other by a connecting structure that is a cross-linker compound of the general formula (1):
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Abstract
The invention provides a tri- or tetra-valent monospecific antigen-binding protein comprising three or four Fab fragments bound to each other covalently by a connecting structure, which protein is not a natural immunoglobuline. Further provided are novel connecting structures for use in assembling the proteins of the invention and means for attaching a labeling or effector group thereto. The proteins of the invention are useful, for example, in the treatment and diagnosis of cancer.
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8 Claims
- 1. A tri- or tetra-valent monospecific antigen-binding protein comprising three or four Fab fragments bound to each other by a connecting structure that is a cross-linker compound of the general formula (1):
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