Optimized high-throughput analytical system
First Claim
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1. A method for performing a serial analysis in a microfluidic channel network, comprising:
- selecting a cycle length of a test plug containing a test compound plug and a spacer plug;
identifying a diffusion coefficient of the test compound in the test compound plug;
selecting a total reaction time for the test compound;
determining one or more of a maximum channel cross-sectional dimension and a channel length for carrying out the analysis, based upon the cycle length, diffusion coefficient and total reaction time, whereby the test compound in the test compound plug disperses a distance that is less than 200% of the test compound plug length during the total reaction time;
providing at least a first microfluidic channel that comprises one or more of the maximum channel cross-sectional dimension and channel length;
introducing at least a first test plug having the cycle length into the at least first microfluidic channel; and
analyzing the test compound in the first microfluidic channel.
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Abstract
Throughput rates for microfluidic serial analysis systems are optimized by maximizing the proximity and speed with which multiple different samples may be serially introduced into a microfluidic channel network. Devices are included that include optimized parameters based upon desired throughput rates for a given set of reagents, reaction times and the like.
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Citations
15 Claims
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1. A method for performing a serial analysis in a microfluidic channel network, comprising:
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selecting a cycle length of a test plug containing a test compound plug and a spacer plug;
identifying a diffusion coefficient of the test compound in the test compound plug;
selecting a total reaction time for the test compound;
determining one or more of a maximum channel cross-sectional dimension and a channel length for carrying out the analysis, based upon the cycle length, diffusion coefficient and total reaction time, whereby the test compound in the test compound plug disperses a distance that is less than 200% of the test compound plug length during the total reaction time;
providing at least a first microfluidic channel that comprises one or more of the maximum channel cross-sectional dimension and channel length;
introducing at least a first test plug having the cycle length into the at least first microfluidic channel; and
analyzing the test compound in the first microfluidic channel. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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Specification