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Optimized high-throughput analytical system

  • US 6,511,853 B1
  • Filed: 08/02/2000
  • Issued: 01/28/2003
  • Est. Priority Date: 01/19/1999
  • Status: Expired due to Term
First Claim
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1. A method for performing a serial analysis in a microfluidic channel network, comprising:

  • selecting a cycle length of a test plug containing a test compound plug and a spacer plug;

    identifying a diffusion coefficient of the test compound in the test compound plug;

    selecting a total reaction time for the test compound;

    determining one or more of a maximum channel cross-sectional dimension and a channel length for carrying out the analysis, based upon the cycle length, diffusion coefficient and total reaction time, whereby the test compound in the test compound plug disperses a distance that is less than 200% of the test compound plug length during the total reaction time;

    providing at least a first microfluidic channel that comprises one or more of the maximum channel cross-sectional dimension and channel length;

    introducing at least a first test plug having the cycle length into the at least first microfluidic channel; and

    analyzing the test compound in the first microfluidic channel.

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