Method and apparatus for treatment of congestive heart failure by improving perfusion of the kidney

• US 6,514,226 B1
• Filed: 02/10/2000
• Issued: 02/04/2003
• Est. Priority Date: 02/10/2000
• Status: Active Grant

• Current Assignee: Gambro Lundia AB (Baxter International Inc.)
• Original Assignee: CHF Solutions, Inc.
• Inventors: Levin, Howard R., Gelfand, Mark
• Primary Examiner(s): JACYNA, J CASIMER
• Application Number:
  US09/501,234
• Time in Patent Office: 1,090 Days
• Field of Search: 604/4.01, 604/6.11, 604/8, 604/9, 604/131, 604/151, 604/507, 604/508, 128/898, 600/16, 623/3.1
• US Class Current: 604/9
• CPC Class Codes: A61M 1/3621 Extra-corporeal blood circuits single-needle circuits A61M1/30
• CPC Class Codes: A61M 1/3653 Interfaces between patient blood circulation and extra-corporal blood circuit
• CPC Class Codes: A61M 1/3659 Cannulae pertaining to extracorporeal circulation
• CPC Class Codes: A61M 2027/004 with at least a part of the circuit outside the body

Abstract

A method for treating congestive heart failure (CHF) has been developed that restores kidney renal functions by artificially perfusion of at least one kidney. The kidney is perfused with the patient'"'"'s blood or other suitable perfusion fluid. A catheter inserted into the aorta of the patient has a distal end that supplies the perfusion fluid into a renal artery of the patient. The catheter may be coupled to an implanted blood pump or to an external supply of perfusion pressure. The restoration of kidney function assists the heart by removing excess fluid, urine and toxin from the patient, and by normalizing the patient'"'"'s renin-angiotensin system and other neurohormonal substances. The method is applicable to treat chronic and acute CHF.

Claims

1. A method to treat congestive heart failure in a patient comprising the steps of:

a. artificially perfusing at least one kidney in the patient with a perfusion fluid by withdrawing venous blood from the patient and infusing as the perfusion fluid the blood withdrawn from the patient into at least one kidney;

b. restoration of a predetermined functional level of renal function of said kidney;

c. ceasing the artificial perfusing step after the predetermined functional level has been achieved, or a predetermined time of treatment has elapsed.

2. A method to treat congestive heart failure as in claim 1 wherein steps (a), (b) and (c) are repeated on a periodic basis to treat chronic congestive heart failure.

3. A method to treat congestive heart failure as in claim 2 the periodic basis is an intermittent repetition of steps (a), (b) and (c) over a period of up to six weeks.

4. A method to treat congestive heart failure as in claim 1 wherein steps (a), (b) and (c) are performed to treat acute congestive heart failure.

5. A method to treat congestive heart failure as in claim 1 wherein step (a) is performed for a short-term period of less than 24 hours before step (b) is achieved.

6. A method to treat congestive heart failure as in claim 1 wherein step (a) is performed for a short-term period of less than three days before step (b) is achieved.

7. A method to treat congestive heart failure as in claim 1 wherein the restoration of a baseline renal function comprises returning a normal perfusion pressure to the at least one kidney after step (a).

8. A method to treat congestive heart failure as in claim 1 wherein said kidney is perfused in step (a) and a second kidney of the patient is not perfused.

9. A method to treat congestive heart failure as in claim 1 wherein both kidneys are in the patient having two kidneys.

10. A method to treat congestive heart failure as in claim 1 wherein step (a) is performed by an implanted blood pump in the patient that provides the perfusion fluid to the at least one kidney.

11. A method to treat congestive heart failure as in claim 1 wherein the perfusion blood is a mixture of venous and arterial blood.

12. A method to treat congestive heart failure as in claim 1 further comprising the step of controlling a pressure of the perfusion fluid in step (a) such that the pressure is within a normal autoregulatory range of a perfusion pressure for the at least one kidney.

13. A method to treat congestive heart failure as in claim 1 further comprising the step of controlling a pressure of the perfusion fluid in step (a) such that the pressure is higher than the normal autoregulatory range but lower than the pressure that will cause barotrauma of the kidney.

14. A method to treat congestive heart failure as in claim 1 wherein the baseline renal function is determined by monitoring a urine output of the patient.

15. A method to treat congestive heart failure as in claim 1 wherein the functional level is a baseline renal function that is determined by monitoring a blood pressure of the patient.

16. A method to treat congestive heart failure as in claim 15 wherein the blood pressure being monitored is arterial pressure.

17. A method to treat congestive heart failure as in claim 15 wherein the blood pressure monitored is venous blood pressure.

18. A method to treat congestive heart failure as in claim 1 wherein the predetermined functional level is a baseline renal function that is determined by monitoring the weight of the patient.

19. A method to treat congestive heart failure in a patient comprising the steps of:

a) artificially perfusing at least one kidney in the patient with a perfusion fluid having a perfusion fluid pressure;

b) adjusting the perfusion fluid pressure to fall within a predetermined pressure range;

c) monitoring the patient for a predetermined desired improvement in a condition related to the congestive heart failure;

d) if the desired improvement is not achieved, then changing the predetermined pressure range and repeating steps (a) and (b) until the improvement is achieved.