Systems for delivering a cosmetic and/or therapeutic active to oral surfaces using an integral carrier

• US 6,514,484 B2
• Filed: 02/28/2002
• Issued: 02/04/2003
• Est. Priority Date: 03/19/2001
• Status: Expired due to Fees

• Current Assignee: The Procter & Gamble Company
• Original Assignee: The Procter & Gamble Company
• Inventors: Rajaiah, Jayanth, Glandorf, William Michael, Ha, Thinh Nguyen, Ernst, Lisa Catron, Mayer, Christopher Robert, Case, Ann Maria
• Primary Examiner(s): Rose, Shep K.
• Application Number:
  US10/084,896
• Publication Number:
  US 20020176827A1
• Time in Patent Office: 341 Days
• Field of Search: 424/49-58
• US Class Current: 424/53
• CPC Class Codes: A61C 19/063 Medicament applicators for teeth or gums, e.g. treatment with fluorides
• CPC Class Codes: A61K 8/0208 Tissues; Wipes; Patches
• CPC Class Codes: A61K 8/8111 Homopolymers or copolymers of aliphatic olefines, e.g. polyethylene, polyisobutene; Compositions of derivatives of such polymers
• CPC Class Codes: A61P 1/02 Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

Systems for delivering cosmetic and therapeutic actives to the oral cavity employ a strip comprising a first layer of material, a second layer comprising polybutene with a molecular weight of about 300 to about 3000, and a cosmetic or therapeutic active included within the second layer. Therapeutic and cosmetic actives in compositions comprising polybutene inhibit or prevent gingivitis, caries, staining, fungi, bacteria and plaque build-up in the oral cavity by means of the delivery system.

Claims

1. A delivery system for delivering stain bleaching or tooth whitening actives to the oral surfaces comprising:

a) a flexible strip of material, and adhered to or coated thereon

b) a composition comprising a mixture of polybutene with a molecular weight of about 300 to about 3000 said polybutene being a non-mucoadhesive flowable liquid that does not exhibit elastic, elastomeric, or rubbery behavior or properties and is not cross-linked, and one or more stain bleaching, tooth whitening actives, releasably associated to the flexible strip of material.

2. The delivery system according to claim 1 wherein the amount of said composition is less than about 0.2 grams/cm².

3. The delivery system according to claim 1 wherein said flexible strip of material having sufficient flexibility to form a curved shape on an oral surface, said strip of material being conformable to the oral surface without permanent deformation when said delivery system is placed thereagainst and wherein said flexible strip of material comprises a first side and a second side and wherein said composition is applied to said second side of said flexible strip of material.

4. The delivery system according to claim 3 wherein the flexible strip of material has a width of about 0.5 to about 4 centimeters.

5. The delivery system according to claim 3 wherein the flexible strip of material has a length of about 2 cm to about 12 centimeters.

6. The delivery system according to claim 3 wherein the flexible strip of material further comprises a plurality of pockets.

7. The delivery system according to claim 3 wherein the flexible strip of material has a thickness of less than 1 millimeter.

8. The delivery system according to claim 1 wherein the polybutene has a molecular weight of about 500 to about 2200.

9. The delivery system according to claim 8 wherein the polybutene has a molecular weight of about 750 to about 1500.

10. The delivery system according to claim 1 wherein the amount of the stain bleaching, tooth whitening active agent is a unit dose.

11. The delivery system according to claim 1 wherein the stain bleaching, tooth whitening active agent is selected from the group consisting of peroxides, metal chloites, perborates, percarbonates, peroxyacids, persulfates, and combinations thereof.

12. The delivery system according to claim 11 wherein the stain bleaching tooth whitening active agent is selected from the group consisting of hydrogen peroxide, urea peroxide, calcium peroxide, carbamide peroxide, calcium chlorite, barium chlorite, magnesium chlorite, lithium chlorite, sodium chlorite, potassium chlorite, hypochlorite, chlorine dioxide, sodium percarbonate, oxones and combinations thereof.

13. The delivery system according to claim 12 wherein the stain bleaching, tooth whitening active agent is carbamide peroxide.

14. The delivery system according to claim 1 wherein the composition further comprises a viscosity modifier.

15. A oral care product comprising:

a) a package; and

b) one or more delivery systems for delivering oral care active to the oral surfaces comprising;

a flexible strip of material, and a composition comprising a mixture of polybutene with a molecular weight of about 300 to about 3000 said polybutene being a non-mucoadhesive flowable liquid that does not exhibit elastic, elastomeric, or rubbery behavior or properties and is not cross-linked and one or more stain bleaching tooth whitening active agents, releasably associated to the flexible strip of material, disposed within said package.

16. A method of providing sustained release of stain bleaching, tooth whitening actives to oral surfaces by delivering with a flexible strip of material a composition comprising polybutene with a molecular weight of about 300 to about 3000 said polybutene being a non-m ucoadhesive flowable liquid that does not exhibit elastic, elastomeric, or rubbery behavior or properties and is not cross-linked, mixed with and a stain bleaching, tooth whitening active, to said oral surfaces.

17. The method according of claim 16 wherein the stain bleaching, tooth whitening active agent is carbamide peroxide.

18. A method of inhibiting and preventing gingivitis, caries, staining, fungi, bacteria and plaque build up in the oral cavity by delivering with a flexible strip of material a composition comprising polybutene with a molecular weight of about 300 to about 3000 said polybutene being a non-mucoadhesive flowable liquid that does not exhibit elastic, elastomeric, or rubbery behavior or properties and is not cross-linked, to said oral surfaces.