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Method for enhancing an immune response

  • US 6,514,948 B1
  • Filed: 07/02/1999
  • Issued: 02/04/2003
  • Est. Priority Date: 07/02/1999
  • Status: Expired due to Fees
First Claim
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1. A method for enhancing an immune response to an antigenic substance, comprising administering intranasally a polynucleotide comprising an immunostimulatory nucleotide sequence (ISS) to a subject antigenic about one day to about seven days prior to exposure to the antigenic substance by the subject, wherein the ISS comprises the sequence 5′

  • -rrcgyy-3′

    (SEQ ID NO;

         1), 5′

    -rycgyy-3′

    (SEQ ID NO;

         2), 5′

    -rrcgyycg-3′

    (SEQ ID NO;

         3) or 5′

    -rycgyycg-3′

    (SEQ ID NO;

         4), andwherein upon exposure to the antigenic substance, an immune response specific for the antigenic substance antigenic is enhanced relative to an immune response produced by administration of the substance alone.

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