Apparatus and method for tissue capture

• US 6,517,498 B1
• Filed: 07/20/2000
• Issued: 02/11/2003
• Est. Priority Date: 03/03/1998
• Status: Expired due to Term

• Current Assignee: Senorx Incorporated (Becton, Dickinson & Co)
• Original Assignee: Senorx Incorporated (Becton, Dickinson & Co)
• Inventors: Homet, William C., Burbank, Fred H., Lubock, Paul
• Primary Examiner(s): Shaver, Kevin
• Assistant Examiner(s): MARMOR II, CHARLES ALAN
• Application Number:
  US09/619,867
• Time in Patent Office: 936 Days
• Field of Search: 600/562, 600/564, 600/566, 600/567, 606/39, 606/41, 606/45-48, 606/51, 606/52, 606/110, 606/113-115, 606/167, 606/170
• US Class Current: 600/564
• CPC Class Codes: A61B 10/02 Instruments for taking cell samples or for biopsy A61B10/0038 and A61B10/0045 take precedence; needle locating or guiding means A61B17/3403; samplers for enzymology or microbiology C12M1/26; sampling or preparing biological specimens G01N33/48
• CPC Class Codes: A61B 10/0233 Pointed or sharp biopsy instruments
• CPC Class Codes: A61B 10/0266 means for severing sample
• CPC Class Codes: A61B 10/0275 with sample notch, e.g. on the side of inner stylet
• CPC Class Codes: A61B 10/0283 with vacuum aspiration, e.g. caused by retractable plunger or by connected syringe A61B10/025, A61B10/0266 take precedence
• CPC Class Codes: A61B 17/32056 Surgical snare instruments for removing or smashing calculi A61B2017/2212; tonsillotomes A61B17/26
• CPC Class Codes: A61B 17/320725 with radially expandable cutting or abrading elements A61B17/32075 takes precedence
• CPC Class Codes: A61B 17/3417 Details of tips or shafts, e.g. grooves, expandable, bendable; Multiple coaxial sliding cannulas, e.g. for dilating syringe needles A61M5/32; dilators A61M29/00
• CPC Class Codes: A61B 18/14 Probes or electrodes therefor
• CPC Class Codes: A61B 18/1482 having a long rigid shaft for accessing the inner body transcutaneously in minimal invasive surgery, e.g. laparoscopy
• CPC Class Codes: A61B 18/1487 Trocar-like, i.e. devices producing an enlarged transcutaneous opening
• CPC Class Codes: A61B 18/1492 having a flexible, catheter-like structure, e.g. for heart ablation A61B18/1477 takes precedence
• CPC Class Codes: A61B 2010/0208 Biopsy devices with actuators, e.g. with triggered spring mechanisms
• CPC Class Codes: A61B 2010/0225 for taking multiple samples
• CPC Class Codes: A61B 2017/32004 having a laterally movable cutting member at its most distal end which remains within the contours of said end
• CPC Class Codes: A61B 2018/00208 actively driven, e.g. by a motor
• CPC Class Codes: A61B 2018/00214 Expandable means emitting energy, e.g. by elements carried thereon
• CPC Class Codes: A61B 2018/00267 having a basket shaped structure
• CPC Class Codes: A61B 2018/00333 Breast
• CPC Class Codes: A61B 2018/00898 Alarms or notifications created in response to an abnormal condition
• CPC Class Codes: A61B 2018/0091 : Handpieces of the surgical instrument or device
• CPC Class Codes: A61B 2018/00916 : with means for switching or controlling the main function of the instrument or device
• CPC Class Codes: A61B 2018/1253 : monopolar
• CPC Class Codes: A61B 2018/126 : bipolar
• CPC Class Codes: A61B 2018/1407 : Loop
• CPC Class Codes: A61B 2018/1475 : Electrodes retractable in or deployable from a housing
• CPC Class Codes: A61B 2018/162 : located on the probe body
• CPC Class Codes: A61B 2090/3908 : Soft tissue, e.g. breast tissue
• CPC Class Codes: A61B 90/37 : Surgical systems with images on a monitor during operation

Abstract

A tissue acquisition system includes electrodes that are energized by a radio frequency (RF) energy source. Retractable electrodes are energized and extended from a cannula and the cannula is advanced in the tissue to position the cannula near the target tissue site in a patient. The retractable electrodes are then retracted and a distal electrode cuts a tissue sample from the tissue site when the cannula is further advanced into the tissue. The retractable electrodes are then energized and extended from the cannula and the cannula is rotated to separate the tissue sample from the tissue site. The tissue sample is ejected through the cannula for collection by advancing a dilator.

Claims

1. A tissue acquisition device for retrieving tissue samples from a patient, comprising:

a cannula having a proximal end, a distal end, a longitudinal axis extending between the proximal and distal ends, and a tissue lumen extending along the longitudinal axis from the proximal end toward the distal end;

a distal electrode which has a lumen that is substantially aligned with the cannula tissue lumen and which is secured to the distal end of the cannula; and

at least two retractable electrodes extendable distally from the distal end of the cannula.

2. The tissue acquisition device in accordance with claim 1, wherein the distal electrode and the cannula are generally circular in cross sectional shape and the lumen of the distal electrode is substantially coaxial with the cannula tissue lumen.

3. The tissue acquisition device in accordance with claim 1, further comprising at least one distal electrode support that extends generally parallel to the cannula longitudinal axis along an outer surface of the cannula from generally the cannula proximal end to generally the cannula distal end, the distal electrode support having a distal end in electrical contact with the distal electrode.

4. The tissue acquisition device in accordance with claim 3, further comprising a plurality of distal electrode supports that extend generally parallel to the cannula longitudinal axis along an outer surface of the cannula from generally the cannula proximal end to generally the cannula distal end, each of the distal electrode supports having distal ends in electrical contact with the distal electrode.

5. The tissue acquisition device in accordance with claim 4, further comprising a sheath covering the cannula, the retractable electrode and the distal electrode supports and extending generally from the cannula proximal end to the cannula distal end.

6. The tissue acquisition device in accordance with claim 1, further comprising a dilator movably positioned in the cannula tissue lumen.

7. The tissue acquisition device in accordance with claim 1, wherein the at least two retractable electrodes comprise a pair of opposing retractable electrodes located externally of the cannula and extending generally from the proximal end of the cannula to generally the distal end of the cannula when in a retracted position.

8. The tissue acquisition device in accordance with claim 7, wherein the distal electrode and the retractable electrodes are electrically connected to an energy source.

9. The tissue acquisition device in accordance with claim 8, wherein the energy source is an RF energy source.

10. The tissue acquisition device in accordance with claim 7, wherein the retractable electrodes are disposed in a housing when retracted and have a first configuration when retracted and a second configuration when distally extended from the housings which extends at least partially towards the longitudinal axis of the cannula.

11. The tissue acquisition device in accordance with claim 10, wherein the retractable electrodes in the second configuration extend distally of the distal electrode and cross the longitudinal axis of the cannula.

12. The tissue acquisition device in accordance with claim 10, wherein the retractable electrodes each have an apex that extends radially farther from the longitudinal axis of the cannula than an outer surface of the cannula when in the second configuration.

13. The tissue acquisition device in accordance with claim 1 wherein the cannula tissue lumen further comprises a lubricious coating on an inner surface thereof.

14. A system for sampling tissue from a patient, comprising:

a RF energy generator capable of generating RF energy; and

a tissue acquisition device in accordance with claim 1, wherein the distal electrode and the at least two retractable electrodes of the tissue acquisition device are in electrical communication with the RF energy generator.

15. The system in accordance with claim 14, further comprising a vacuum source in fluid communication with the cannula tissue lumen.

16. The system in accordance with claim 14 wherein the at least two retractable electrodes comprise a pair of opposing retractable electrodes having a first configuration when retracted, a second configuration when extended in which the retractable electrodes extend distally of the distal electrode and cross the longitudinal axis of the cannula and an apex that extends radially farther from the longitudinal axis of the cannula than an outer surface of the cannula when in the second configuration.

17. A method of sampling tissue from a patient, comprising:

(a) providing a tissue acquisition device having;

a cannula having a proximal end, a distal end, a longitudinal axis extending between the proximal and distal ends, and a tissue lumen extending along the longitudinal axis from the distal end of the cannula;

a distal electrode which has a lumen that is substantially aligned with the cannula tissue lumen and which is secured to the distal end of the cannula; and

at least two retractable electrodes extendable distally from the distal end of the cannula;

p1 (b) inserting the cannula into target tissue of a patient with the distal electrode energized such that at least a portion of the target tissue enters the cannula tissue lumen;

(c) extending the at least two retractable electrodes;

(d) energizing the at least two retractable electrodes; and

(e) separating the target tissue within the cannula tissue lumen by rotating the cannula and the at least two retractable electrodes through the tissue of the patient with the at least two retractable electrodes energized.

18. The method of sampling tissue from a patient in accordance with claim 17, wherein the distal electrode and the at least two retractable electrodes are energized by applying RF energy to the electrodes.

19. The method of sampling tissue from a patient in accordance with claim 17, further comprising aspirating a tissue sample through the tissue lumen of the cannula.

20. The method of sampling tissue from a patient in accordance with claim 17, wherein the at least two retractable electrodes comprise a pair of opposing retractable electrodes extending generally from the proximal end of the cannula to generally the distal end of the cannula when in a retracted position, and further comprising extending the two opposing retractable electrodes from the cannula and energizing the two opposing retractable electrodes prior to separating the target tissue within the cannula tissue lumen from the surrounding tissue.

21. The method of sampling tissue from a patient in accordance with claim 20, wherein the two opposing retractable electrodes have a first configuration when retracted, a second configuration when extended in which the retractable electrodes extend distally of the distal electrode and overlap each other and an apex that extends radially farther from the longitudinal axis of the cannula than an outer surface of the cannula.

22. The method of sampling tissue from a patient in accordance with claim 20 further comprising energizing the opposing retractable electrodes by applying RF energy to the retractable electrodes.

23. The method of sampling tissue from a patient in accordance with claim 20, wherein the cannula is rotated at least 180 degrees to separate the tissue sample from the patient.

24. The method sampling tissue from a patient in accordance with claim 20, wherein the cannula is rotated approximately 180 to 270 degrees to separate the tissue sample from the patient.

25. The method of sampling tissue from a patient in accordance with claim 20, wherein the cannula is rotated approximately 180 to 210 degrees to separate the tissue sample from the patient.

26. The method of sampling tissue from a patient in accordance with claim 17, wherein at least three retractable electrodes are extended into the tissue of a patient.