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Method for diagnosing an increased risk for thrombosis or a genetic defect causing thrombosis and kit for use with the same

  • US 6,518,016 B1
  • Filed: 06/06/1995
  • Issued: 02/11/2003
  • Est. Priority Date: 02/14/1994
  • Status: Expired due to Term
First Claim
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1. A method for diagnosing an increased risk for thrombosis or a genetic defect causing thrombosis comprising the steps of:

  • (A) obtaining, from a test subject, test nucleic acid comprising codon 506 within EXON 10 of the human Factor V gene; and

    (B) assaying for the presence of a point mutation in the nucleotides of codon 506 within EXON 10 of the human Factor V gene, wherein said point mutation correlates to a decrease in the degree of inactivation of human Factor V and/or human Factor Va by activated protein C, wherein the presence of said point mutation in said test nucleic acid indicates an increased risk for thrombosis or a genetic defect causing thrombosis.

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