Significance of dosimetry in photodynamic therapy of injured arteries
First Claim
1. A method for modulating restenosis in a subject, comprising the steps of non-systemically administering a therapeutically effective amount of a benzoporphyrin derivative or methylene blue to an injury site in vivo and irradiating the injury site with sufficient light energy between about 300 and 900 nm, such that undesired cells at the injury site are destroyed and restenosis in the subject is modulated.
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Abstract
Photodynamic therapy (PDT), the light activation of methylene blue or benzoporphyrin derivatives to produce free-radicals, was shown in vivo to inhibit intimal hyperplasia (IH) and restenosis. The present invention provides an effective clinical approach for PDT treatment which modulates the vascular intervention injury healing response.
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Citations
15 Claims
- 1. A method for modulating restenosis in a subject, comprising the steps of non-systemically administering a therapeutically effective amount of a benzoporphyrin derivative or methylene blue to an injury site in vivo and irradiating the injury site with sufficient light energy between about 300 and 900 nm, such that undesired cells at the injury site are destroyed and restenosis in the subject is modulated.
- 8. A method for modulating intimal hyperplasia in a subject, comprising the steps of non-systemically administering a therapeutically effective amount of a benzoporphyrin derivative or methylene blue to undesired cells of a target tissue site in vivo and irradiating the undesired cells of the target tissue treated injury site with a sufficient amount of light energy between about 300 and 900 nm, such that the undesired cells of the target tissue are eradicated.
Specification