Porous three dimensional structure
First Claim
1. A porous three dimensional structure for implantation in a host animal capable of producing an inflammatory foreign body response, the structure comprising first and second layers spaced by a plurality of posts having a predetermined length connecting the first and second layers, each of the layers having a plurality of openings of a predetermined size permitting fluids and inflammatory cells of the animal to pass through the openings and migrate into an interior volume defined by the first and second layers, and wherein the width of each of the plurality of openings is less than about 20 μ
- m and the size of the openings and length of the posts promote a non-flattened morphology of the cells, and wherein the structure promotes vascularization adjacent to the structure when implanted into the animal.
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Accused Products
Abstract
A porous three dimensional structure for implantation in a host animal capable of producing an inflammatory foreign body response. The structure includes first and second layers spaced by a plurality of posts having a predetermined length connecting the first and second layers. Each of the layers has a plurality of openings of a predetermined size permitting fluids and inflammatory cells of the animal to pass through the openings and migrate into an interior volume defined by the first and second layers. The size of the openings and length of the posts promote a non-flattened morphology of the cells. The structure promotes vascularization adjacent to the structure when implanted into the animal.
452 Citations
44 Claims
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1. A porous three dimensional structure for implantation in a host animal capable of producing an inflammatory foreign body response, the structure comprising first and second layers spaced by a plurality of posts having a predetermined length connecting the first and second layers, each of the layers having a plurality of openings of a predetermined size permitting fluids and inflammatory cells of the animal to pass through the openings and migrate into an interior volume defined by the first and second layers, and wherein the width of each of the plurality of openings is less than about 20 μ
- m and the size of the openings and length of the posts promote a non-flattened morphology of the cells, and wherein the structure promotes vascularization adjacent to the structure when implanted into the animal.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33)
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34. A porous three dimensional structure for implantation in a host animal capable of producing an inflammatory foreign body response, the structure comprising first and second layers spaced by a spacer connecting the first and second layers, each of the layers having a plurality of openings of a predetermined size permitting fluids and inflammatory cells of the animal to pass through the openings and migrate into an interior volume defined by the first and second layers, wherein the width of each of the plurality of openings is less than about 20 μ
- m and the size of the openings promote a non-flattened morphology of the cells, and wherein the structure promotes vascularization adjacent to the structure when implanted in the animal, and wherein each of the plurality of openings in the first layer is aligned with a corresponding opening of the plurality of openings in the second layer.
- View Dependent Claims (35, 36)
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37. A porous three dimensional structure for implantation in a host animal capable of producing an inflammatory foreign body response, the structure comprising first and second layers spaced by a plurality of posts having a predetermined length connecting the first and second layers, each of the layers having a plurality of openings of a predetermined size permitting fluids and inflammatory cells of the animal to pass through the openings and migrate into interior scaffolds defined by said openings and said plurality of posts, and wherein the width of each of the plurality of openings is less than about 20 μ
- m and each of said scaffolds is sized and shaped to promote a non-flattened morphology of the cells, and wherein the structure promotes vascularization adjacent to the structure when implanted into the animal.
- View Dependent Claims (38, 39, 40, 41, 42, 43, 44)
Specification