MRI-guided temperature mapping of tissue undergoing thermal treatment

• US 6,522,142 B1
• Filed: 12/14/2001
• Issued: 02/18/2003
• Est. Priority Date: 12/14/2001
• Status: Expired due to Term

• Current Assignee: InSightec Ltd.
• Original Assignee: Insightec-Txsonics Limited
• Inventors: Freundlich, David
• Primary Examiner(s): Lefkowitz, Edward
• Assistant Examiner(s): Shrivastav, Brij B.
• Application Number:
  US10/022,758
• Time in Patent Office: 431 Days
• Field of Search: 324/315, 324/318, 324/309, 324/322, 324/307, 600/411, 600/421
• US Class Current: 324/315
• CPC Class Codes: A61B 2017/00084 Temperature
• CPC Class Codes: A61B 2090/374 NMR or MRI
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00
• CPC Class Codes: G01R 33/4804 Spatially selective measurement of temperature or pH

Abstract

Systems and methods using magnetic resonance imaging for monitoring the temperature of a tissue mass being heated by energy converging in a focal zone that is generally elongate and symmetrical about a focal axis. A first plurality of images of the tissue mass are acquired in a first image plane aligned substantially perpendicular to the focal axis. A cross-section of the focal zone in the first image plane is then defined from the first plurality of images. A second plurality of images are acquired of the tissue mass in a second image plane aligned substantially parallel to the focal axis, the second image plane bisecting the first image plane at approximately a midpoint of the defined focal zone cross-section.

Claims

1. A method using magnetic resonance imaging for monitoring the temperature of a tissue mass being heated in a focal zone encompassing at least a portion of the tissue mass, the focal zone being generally elongate and symmetrical about a focal axis, the method comprising:

acquiring a first plurality of images of the tissue mass in a first image plane aligned substantially perpendicular to the focal axis;

defining a cross-section of the focal zone in the first image plane from the first plurality of images; and

acquiring a second plurality of images of the tissue mass in a second image plane aligned substantially parallel to the focal axis, the second image plane bisecting the first image plane at approximately a midpoint of the defined focal zone cross-section, such that images acquired in the first plane are substantially orthogonal to images acquired in the second plane.

2. The method of claim 1, wherein heating energy is applied for a defined heating period, and wherein an image of the second plurality of images is acquired proximate the end of the heating period.

3. The method of claim 1, further comprising

deriving a three-dimensional thermal evolution of the portion of the tissue mass in the focal zone based on the first and second pluralities of images.

4. The method of claim 3, wherein the thermal evolution is derived by

defining a cross-section of the focal zone in the second image plane from the second plurality of images, the cross-section of the focal zone in the second image plane having a length, and

extrapolating the cross-section of the focal zone in the first image plane along the length of the cross-section of the focal zone in the second image plane.

5. The method of claim 3, further comprising

verifying that the temperature of the tissue mass in the focal zone exceeded a threshold temperature or thermal dose based on the derived thermal evolution.

6. The method of claim 1, further comprising

acquiring one or more additional images of the tissue mass in the focal zone in a third image plane aligned substantially perpendicular to the focal axis while acquiring the images of the second plurality of images,

defining a cross-section of the focal zone in the third image plane, and

verifying that the second imaging plane bisects the third image plane at approximately a midpoint of the defined focal zone cross-section in the third image plane.

7. A method using magnetic resonance imaging for monitoring the temperature of a tissue mass being heated in a focal zone encompassing at least a portion of the tissue mass, the focal zone being generally elongate and symmetrical about a focal axis, the method comprising:

acquiring a first plurality of images of the tissue mass in a first image plane aligned substantially perpendicular to the focal axis;

defining a cross-section of the focal zone in the first image plane from the first plurality of images;

acquiring a second plurality of images of the tissue mass in a second image plane aligned substantially parallel to the focal axis, the second image plane bisecting the first image plane at approximately a midpoint of the defined focal zone cross-section; and

deriving a three-dimensional thermal evolution of the tissue mass in the focal zone based on the first and second pluralities of images.

8. The method of claim 7, wherein the heating energy is applied for a defined heating period, and wherein an image of the second plurality of images is acquired proximate an end of the heating period.

9. The method of claim 7, wherein the thermal evolution is derived by defining a cross-section of the focal zone in the second image plane from the second plurality of images, the cross-section of the focal zone in the second image plane being generally longitudinal and having a length, and

extrapolating the cross-section of the focal zone in the first image plane along the length of the cross-section of the focal zone in the second image plane.

10. The method of claim 7, further comprising

verifying that the temperature of the tissue mass in the focal zone exceeded a threshold temperature or thermal dose based on the derived thermal evolution.

11. The method of claim 7, further comprising

acquiring one or more additional images of the tissue mass in the focal zone in a third image plane aligned substantially perpendicular to the focal axis while acquiring the images of the second plurality of images,

defining a cross-section of the focal zone in the third image plane, and

verifying that the second imaging plane bisects the third image plane at approximately a midpoint of the defined focal zone cross-section in the third image plane.

12. A system for monitoring changes in temperature of a tissue mass being heated by energy converging in a focal zone encompassing at least a portion of the tissue mass, the focal zone generally elongate and symmetrical about a focal axis, the system configured to:

acquire a first plurality of magnetic resonance images of the tissue mass in a first image plane aligned substantially perpendicular to the focal axis;

define a cross-section of the focal zone in the first image plane from the first plurality of images; and

acquire a second plurality of images of the tissue mass in a second image plane aligned substantially parallel to the focal axis, the second image plane bisecting the first image plane at approximately a midpoint of the defined focal zone cross-section.

13. The system of claim 12, wherein the heating energy is applied for a defined heating period, and wherein an image of the second plurality of images is acquired proximate an end of the heating period.

14. The system of claim 12, further configured to derive a three-dimensional thermal evolution of the tissue mass in the focal zone based on the first and second pluralities of images.

15. The system of claim 14, wherein the thermal evolution is derived by

defining a cross-section of the focal zone in the second image plane from the second plurality of images, the cross-section of the focal zone in the second image plane having a length,

extrapolating the cross-section of the focal zone in the first image plane along the length of the cross-section of the focal zone in the second image plane, and

determining differences in a characteristic of the tissue mass in the focal zone measured in successive images of the second plurality of images, the differences in the measured characteristic corresponding at least in part to changes in temperature of the tissue mass between respective images.

16. The system of claim 12, further configured to

verify that the temperature of the tissue mass in the focal zone exceeded a threshold temperature or thermal dose based on the derived thermal evolution.

17. The system of claim 15, further configured to

acquire one or more additional images of the tissue mass in the focal zone in a third image plane aligned substantially perpendicular to the focal axis between acquiring images of the second plurality of images,

define a cross-section of the focal zone in the third image plane, and

verify that the second imaging plane bisects the third image plane at approximately a midpoint of the defined focal zone cross-section in the third image plane.

18. A system for monitoring changes in temperature of a tissue mass being heated by energy converging in a focal zone encompassing at least a portion of the tissue mass, the focal zone generally elongate and symmetrical about a focal axis, the system configured to:

acquire a first plurality of magnetic resonance images of the tissue mass in a first image plane aligned substantially perpendicular to the focal axis, the first plurality of images including a baseline image taken prior to the application of ultrasound energy to the tissue mass;

define a cross-section of the focal zone in the first image plane from the first plurality of images; and

acquire a second plurality of images of the tissue mass in a second image plane aligned substantially parallel to the focal axis, the second image plane bisecting the first image plane at approximately a midpoint of the defined focal zone cross-section,

wherein the system derives a three-dimensional thermal evolution of the tissue mass in the focal zone based on the first and second pluralities of images.

19. The system of claim 18, wherein the energy is applied for a defined heating period, and wherein an image of the second plurality of images is acquired proximate an end of the heating period.

20. The system of claim 18, wherein the thermal evolution is derived by

defining a cross-section of the focal zone in the second image plane from the second plurality of images, the cross-section of the focal zone in the second image plane having a length,

extrapolating the cross-section of the focal zone in the first image plane along the length of the cross-section of the focal zone in the second image plane, and

determining differences in a characteristic of the tissue mass in the focal zone measured in successive images of the second plurality of images, the differences in the measured characteristic corresponding at least in part to changes in temperature of the tissue mass between respective images.

21. The system of claim 18, further configured to

verify that the temperature of the tissue mass in the focal zone exceeded a threshold temperature or thermal dose based on the thermal evolution.

22. The system of claim 18, further configured to

acquire one or more additional images of the tissue mass in the focal zone in a third image plane aligned substantially perpendicular to the focal axis between acquiring images of the second plurality of images,

define a cross-section of the focal zone in the third image plane, and

verify that the second imaging plane bisects the third image plane at approximately a midpoint of the defined focal zone cross-section in the third image plane.