Method and system of preventing fouling and corrosion of biomedical devices and structures

• US 6,524,466 B1
• Filed: 07/18/2000
• Issued: 02/25/2003
• Est. Priority Date: 07/18/2000
• Status: Expired due to Fees

• Current Assignee: Apex Semiconductor Incorporated (Acer, Inc.)
• Original Assignee: Apex Semiconductor Incorporated (Acer, Inc.)
• Inventors: Bonaventura, Joseph, Spivack, Arthur J., Ignarro, Louis, Dowling, David B.
• Primary Examiner(s): Bell, Bruce F.
• Application Number:
  US09/618,275
• Time in Patent Office: 952 Days
• Field of Search: 205/724, 205/725, 205/731, 205/734, 205/735, 205/740, 204/196.12, 204/196.16, 204/196.37
• US Class Current: 205/724
• CPC Class Codes: A61L 2420/04 Coatings containing a composite material such as inorganic/organic, i.e. material comprising different phases
• CPC Class Codes: A61L 27/30 Inorganic materials
• CPC Class Codes: A61L 27/50 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: B08B 17/06 by giving articles subject to fouling a special shape or arrangement
• CPC Class Codes: C23F 13/04 Controlling or regulating desired parameters

Abstract

A system for preventing corrosion and/or fouling of a surface of a biomedical device in contact with a corrosive environment comprising:

(a) a semiconductive coating in conductive contact with at least part of the surface; and

(b) an electronic filter for filtering corrosive noise and a method of preventing corrosion and/or fouling using the system.

Claims

1. A method for preventing corrosion of a conductive surface of a biomedical device in contact with a corrosive environment, said method comprising:

(a) coating the conductive surface with a semiconductive coating and providing an electronic filter connected to the coated conductive structure;

(b) monitoring corrosive noise generated by the coated conductive structure and adjusting filter properties of said electronic filter to minimize the corrosive noise, wherein said conductive surface is a surface of a biomedical device selected from the group consisting of artificial joints, and organs.

2. The method of claim 1, wherein said electronic filter comprises a power source and a capacitor.

3. The method of claim 1, wherein said monitoring and adjusting step (b) is performed continually using an active filter and monitoring means.

4. The method of claim 1, wherein said electronic filter comprises a plurality of capacitors and said step (b) further comprises determining a placement of each of said plurality of capacitors on said conductive surface.

5. The method of claim 1, wherein said conductive surface is a metal conductive surface.

6. The method of claim 5, wherein said metal conductive surface comprises a metal selected from the group consisting of ferrous metals and conductive non-ferrous metals.

7. The method of claim 6, wherein said metal is steel.

8. The method of claim 6, wherein said metal is aluminum.

9. The method of claim 6, wherein said metal is stainless steel.

10. The method of claim 6, wherein said metal is titanium.

11. The method of claim 1, wherein said conductive surface is a non-metallic conductive material.

12. The method of claim 11, wherein said non-metallic conductive material is a carbon fiber-epoxy composite.

13. The method of claim 11, wherein said non-metallic conductive material is a carbon nanotube-epoxy composite.

14. The method of claim 11, wherein said non-metallic conductive material is conductive carbon embedded in a physiologically acceptable polymer.

15. The method of claim 1, wherein said semiconductive coating contains both p-type and n-type semiconductor domains.

16. The method of claim 1, wherein said semiconductive coating contains a metal-semiconductor junction.

17. The method of claim 1, wherein said semiconductive coating contains an ionic conductor-semiconductor junction.

18. The method of claim 1, wherein said semiconductive coating contains a metal-semiconductor-ionic conductor junction.

19. The method of claim 1, wherein said semiconductive coating contains a semiconductor-insulator-semiconductor junction.

20. The method of claim 1, wherein said semiconductive coating is a metal/metal oxide/silicate coating.

21. The method of claim 20, wherein said metal/metal oxide/silicate coating is a zinc/zinc oxide/silicate coating.

22. The method of claim 20, wherein said zinc/zinc oxide/silicate coating comprises zinc in an amount of from 80-92% by weight based on dry coating.

23. The method of claim 22, wherein said zinc/zinc oxide/silicate coating comprises zinc in an amount of from 85-89% by weight based on dry coating.

24. The method of claim 20, wherein said metal/metal oxide/silicate coating comprises a metal selected from the group consisting of Zn, Ti, Al, Ga, Ce, Mg, Ba and Cs, and the corresponding metal oxide.

25. The method of claim 24, wherein said metal/metal oxide/silicate coating comprises a mixture of one or more metals selected from the group consisting of Zn, Ti, Al, Ga, Ce, Mg, Ba and Cs and one or more metal oxides obtained therefrom.

26. The method of claim 24, wherein said semiconductive coating further comprises one or more dopants.

27. A system for preventing corrosion or fouling or both of a biomedical device, comprising:

(a) a biomedical device having thereon a semiconductive coating, wherein said biomedical device is a member selected from the group consisting of artificial joints, and organs;

(b) a fixed electronic filter;

(c) a corrosive noise monitoring system; and

(d) an adjustable filter.

28. The system of claim 27, wherein said corrosive noise monitoring system further comprises a high impedance reference electrode and an oscilloscope.

29. The system of claim 27, wherein said adjustable filter is selected from the group consisting of manually adjustable filters and active filters.

30. The system of claim 27, wherein said semiconductive coating contains both p-type and n-type semiconductor domains.

31. The system of claim 27, wherein said semiconductive coating contains a metal-semiconductor junction.

32. The system of claim 27, wherein said semiconductive coating contains an ionic conductor-semiconductor junction.

33. The system of claim 27, wherein said semiconductive coating contains a metal-semiconductor-ionic conductor junction.

34. The system of claim 27, wherein said semiconductive coating contains a semiconductor-insulator-semiconductor junction.

35. The system of claim 27, wherein said semiconductive coating is a metal/metal oxide/silicate coating.

36. The system of claim 35, wherein said metal/metal oxide/silicate coating is a zinc/zinc oxide/silicate coating.

37. The system of claim 36, wherein said zinc/zinc oxide/silicate coating comprises zinc in an amount of from 80-92% by weight based on dry coating.

38. The system of claim 37, wherein said zinc/zinc oxide/silicate coating comprises zinc in an amount of from 85-89% by weight based on dry coating.

39. The system of claim 35, wherein said metal/metal oxide/silicate coating comprises a metal selected from the group consisting of Zn, Ti, Al, Ga, Ce, Mg, Ba and Cs and the corresponding metal oxide.

40. The system of claim 39, wherein said metal/metal oxide/silicate coating comprises a mixture of one or more metals selected from the group consisting of Zn, Ti, Al, Ga, Ce, Mg, Ba and Cs and one or more metal oxides obtained therefrom.

41. The system of claim 39, wherein said semiconductive coating further comprises one or more dopants.

42. The system of claim 27, wherein said conductive surface is a metal conductive surface.

43. The system of claim 42, wherein said metal conductive surface comprises a metal selected from the group consisting of ferrous metals and conductive non-ferrous metals.

44. The system of claim 43, wherein said metal is steel.

45. The system of claim 43, wherein said metal is aluminum.

46. The system of claim 43, wherein said metal is stainless steel.

47. The system of claim 43, wherein said metal is titanium.

48. The system of claim 27, wherein said conductive surface is a non-metallic conductive material.

49. The system of claim 48, wherein said non-metallic conductive material is a carbon fiber-epoxy composite.

50. The system of claim 48, wherein said non-metallic conductive material is a carbon nanotube-epoxy composite.

51. The system of claim 48, wherein said non-metallic conductive material is conductive carbon embedded in a physiologically acceptable polymer.

52. A method for preventing corrosion of a conductive surface of a biomedical device in contact with a corrosive environment, said method comprising:

(a) coating the conductive surface with a semiconductive coating and providing an electronic filter connected to the coated conductive structure;

(b) monitoring corrosive noise generated by the coated conductive structure and adjusting filter properties of said electronic filter to minimize the corrosive noise

wherein the conductive surface is a surface made of a material selected from the group consisting of stainless steel, titanium and non-metallic conductive materials.

53. The method of claim 52, wherein said electronic filter comprises a power source and a capacitor.

54. The method of claim 52, wherein said monitoring and adjusting step (b) is performed continually using an active filter and monitoring means.

55. The method of claim 52, wherein said electronic filter comprises a plurality of capacitors and said step (b) further comprises determining a placement of each of said plurality of capacitors on said conductive surface.

56. The method of claim 52, wherein said conductive surface is stainless steel.

57. The method of claim 52, wherein said conductive surface is titanium.

58. The method of claim 52, wherein said conductive surface is a non-metallic conductive material.

59. The method of claim 58, wherein said non-metallic conductive material is a carbon fiber-epoxy composite.

60. The method of claim 58, wherein said non-metallic conductive material is a carbon nanotube-epoxy composite.

61. The method of claim 58, wherein said non-metallic conductive material is conductive carbon embedded in a physiologically acceptable polymer.

62. The method of claim 52, wherein said conductive surface is a surface of a biomedical device selected from the group consisting of artificial joints, and organs.

63. The method of claim 52, wherein said semiconductive coating contains both p-type and n-type semiconductor domains.

64. The method of claim 52, wherein said semiconductive coating contains a metal-semiconductor junction.

65. The method of claim 52, wherein said semiconductive coating contains an ionic conductor-semiconductor junction.

66. The method of claim 52, wherein said semiconductive coating contains a metal-semiconductor-ionic conductor junction.

67. The method of claim 52, wherein said semiconductive coating contains a semiconductor-insulator-semiconductor junction.

68. The method of claim 52, wherein said semiconductive coating is a metal/metal oxide/silicate coating.

69. The method of claim 68, wherein said metal/metal oxide/silicate coating is a zinc/zinc oxide/silicate coating.

70. The method of claim 68, wherein said zinc/zinc oxide/silicate coating comprises zinc in an amount of from 80-92% by weight based on dry coating.

71. The method of claim 70, wherein said zinc/zinc oxide/silicate coating comprises zinc in an amount of from 85-89% by weight based on dry coating.

72. The method of claim 68, wherein said metal/metal oxide/silicate coating comprises a metal selected from the group consisting of Zn, Ti, Al, Ga, Ce, Mg, Ba and Cs, and the corresponding metal oxide.

73. The method of claim 72, wherein said metal/metal oxide/silicate coating comprises a mixture of one or more metals selected from the group consisting of Zn, Ti, Al, Ga, Ce, Mg, Ba and Cs and one or more metal oxides obtained therefrom.

74. The method of claim 73, wherein said semiconductive coating further comprises one or more dopants.

75. A system for preventing corrosion or fouling or both of a biomedical device, comprising:

(a) a biomedical device having, on a conductive surface thereof, a semiconductive coating, wherein said conductive surface is a material selected from the group consisting of stainless steel, titanium and non-metallic conductive materials;

(b) a fixed electronic filter;

(c) a corrosive noise monitoring system; and

(d) an adjustable filter.

76. The system of claim 75, wherein said corrosive noise monitoring system further comprises a high impedance reference electrode and an oscilloscope.

77. The system of claim 75, wherein said adjustable filter is selected from the group consisting of manually adjustable filters and active filters.

78. The system of claim 75, wherein said semiconductive coating contains both p-type and n-type semiconductor domains.

79. The system of claim 75, wherein said semiconductive coating contains a metal-semiconductor junction.

80. The system of claim 75, wherein said semiconductive coating contains an ionic conductor-semiconductor junction.

81. The system of claim 75, wherein said semiconductive coating contains a metal-semiconductor-ionic conductor junction.

82. The system of claim 75, wherein said semiconductive coating contains a semiconductor-insulator-semiconductor junction.

83. The system of claim 75, wherein said semiconductive coating is a metal/metal oxide/silicate coating.

84. The system of claim 83, wherein said metal/metal oxide/silicate coating is a zinc/zinc oxide/silicate coating.

85. The system of claim 84, wherein said zinc/zinc oxide/silicate coating comprises zinc in an amount of from 80-92% by weight based on dry coating.

86. The system of claim 85, wherein said zinc/zinc oxide/silicate coating comprises zinc in an amount of from 85-89% by weight based on dry coating.

87. The system of claim 83, wherein said metal/metal oxide/silicate coating comprises a metal selected from the group consisting of Zn, Ti, Al, Ga, Ce, Mg, Ba and Cs and the corresponding metal oxide.

88. The system of claim 87, wherein said metal/metal oxide/silicate coating comprises a mixture of one or more metals selected from the group consisting of Zn, Ti, Al, Ga, Ce, Mg, Ba and Cs and one or more metal oxides obtained therefrom.

89. The system of claim 87, wherein said semiconductive coating further comprises one or more dopants.

90. The system of claim 75, wherein said conductive surface is stainless steel.

91. The system of claim 75, wherein said conductive surface is titanium.

92. The system of claim 75, wherein said conductive surface is a non-metallic conductive material.

93. The system of claim 92, wherein said non-metallic conductive material is a carbon fiber-epoxy composite.

94. The system of claim 92, wherein said non-metallic conductive material is a carbon nanotube-epoxy composite.

95. The system of claim 92, wherein said non-metallic conductive material is conductive carbon embedded in a physiologically acceptable polymer.

96. The system of claim 75, wherein said conductive surface is a surface of a biomedical device selected from the group consisting of artificial joints, and organs.