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Targeted Oligonucleotide conjugates

  • US 6,525,031 B2
  • Filed: 08/21/2001
  • Issued: 02/25/2003
  • Est. Priority Date: 06/16/1998
  • Status: Expired due to Term
First Claim
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1. A method of facilitating cellular uptake of a primary moiety comprising:

  • identifying a cell surface receptor on a target cell; and

    contacting said cell with a complex, said complex comprising;

    at least two cell surface receptor ligands; and

    a manifold covalently connected to said primary moiety and to each of said cell receptor ligands, wherein said manifold is a polycyclic molecule.

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