Catheter guidance by magnetocardiographic mapping

• US 6,527,724 B1
• Filed: 06/01/2001
• Issued: 03/04/2003
• Est. Priority Date: 12/04/1998
• Status: Expired due to Fees

• Current Assignee: Consiglio Nazionale Delle Ricerche (Repubblica Italiana)
• Original Assignee: Consiglio Nazionale Delle Ricerche (Repubblica Italiana)
• Inventors: Fenici, Riccardo
• Primary Examiner(s): Bennett, Henry
• Assistant Examiner(s): ROBINSON, DANIEL LEON
• Application Number:
  US09/857,228
• Time in Patent Office: 641 Days
• Field of Search: 600/466, 600/461, 600/459, 600/437, 600/407, 600/434, 600/435, 600/436, 600/467, 600/468, 600/469, 600/470
• US Class Current: 600/466
• CPC Class Codes: A61B 5/06 Devices, other than using radiation, for detecting or locating foreign bodies for removing same A61B17/50 ; determining position of probes within or on the body of the patient
• CPC Class Codes: A61B 5/065 Determining position of the probe employing exclusively positioning means located on or in the probe, e.g. using position sensors arranged on the probe

Abstract

The catheter is constructred of a substantially cylindrical tube, longitudinally subdivided in multiple parallel lumens for wires, available to introduce drives having a distal end with a variable curving, and of fiberoptics for the delivery of energy as laser emission, or different ablation devices. The amagnetic distal electrodes permit the high-resolution mapping of multiple monophasic action potentials just at the arrthythmogenic foci themselves, the magneto cardiographic localization of the catheter and the possible modification of the electrophysiological substrate with the delivery of energy as laser emission. The catheter can be intracardiacally manipulated in the patient with a very high accuracy by exploiting the variability of the curving of the distal end and the sliding thereof into preformed external sheaths, for fitting at the best the threedimensional coordinates thereof with those of the arrhythmogenic substrate, non-invasively predetermined by magnetocardiographic imaging.

Claims

1. A cardiac electrocatheter comprising a plurality of distal electrodes (2, 3, 4, 5), constructed of a non-ferromagnetic and non-polarizable conductor material, shaped in such a manner as to generate simultaneously or sequentially electromagnetic fields of dipolar configuration and with different geometry, at least a more proximal electrode (6;

6bis;

6tris), such electrodes being located at the end of multiple wires (7, 8, 9, 10, 11, 12, 13), of a non-ferromagnetic conductive material, which wires are electrically insulated and twisted one with respect to the other, to avoid, except for the electrodes, magnetic field generation along the catheter during the induction of electromagnetic dipoles at the distal end of the catheter, and a substantially cylindrical flexible tube (1) that sheaths said wires and electrodes, at the distal end thereof leaving exposed a section of the electrode tips and, onto the side wall, near the distal end, a section of said at least one ring-shaped more proximal electrode.

2. The cardiac electrocatheter as per claim 1, wherein at least a further lumen is available for the insertion of fiberoptics (14) or guides of variable geometry.

3. The cardiac electrocatheter as per claim 1, wherein the catheter has four substantially round-shaped or polygon-shaped distal electrodes, and multiple substantially ring-shaped proximal electrodes differently oriented with respect to the longitudinal axis of the catheter.

4. The cardiac electrocatheter as per claim 3, wherein said ring-shaped electrodes have a single or twin wire.

5. The cardiac electrocatheter as per in claim 1, wherein the distal end thereof is longitudinally divided for some millimeters into four flexible and preformed sections and is provided with an external sheath inside which it can slide in such a way that when the catheter is completely retracted inside the external sheath the four distal electrodes, each housed inside one of the four subsections, are substantially parallel, whereas when the catheter is pushed out of the external sheath the four terminal subsections diverge, increasing the distance between the electrode tips.

6. The cardiac electrocatheter as per in claim 5, wherein the distal end thereof is longitudinally divided for more than two millimeters into said four sections.

7. The cardiac electrocatheter as per claim 1, wherein the tip thereof is longitudinally divided for several millimeters into two parallel, flexible and preformed sections and with the four terminal electrodes protruding sideways from one side, housed in pairs inside each subdivision of the tip.

8. The cardiac electrocatheter as per claim 7, wherein the tip thereof is longitudinally divided for more than two millimeters into said two sections.

9. The cardiac electrocatheter as per claim 1, wherein the equivalent surface of the electrodes can vary according to the molecular structure of the material used.

10. The cardiac electrocatheter as per claim 1, wherein the distance between the distal and the more proximal ring-shaped electrodes can vary.

11. The cardiac electrocatheter as per claim 1, wherein the material of which the electrodes are constructed is amagnetic and non-polarizable, and is selected from the group comprising platinated platinum and amorphous carbon, the molecular configuration thereof being variable in such a way as to increase, electrode diameters being equal, the equivalent surface.

12. The cardiac electrocatheter as per claim 1, wherein the material of the wires is an amagnetic material.

13. The cardiac electrocatheter as per claim 1, wherein the flexible tube is constructed of a non-thrombogenic plastic biocompatible material.

14. The cardiac electrocatheter as per claim 13, wherein said material is selected from a group comprising polyurethane, polyvinyl chloride and polyetheramide.

15. The cardiac electrocatheter as per claim 1, wherein the internal gauge of the electrocatheter ranges between 1.7 and 2.7 mm (from 6F to 8F).

16. The cardiac electrocatheter as per claim 1, wherein, besides the lumen housing the electrodes and the wires, the flexible tube is provided with a plurality of other lumens, each running along the body of the catheter in parallel and separate from the others—

with terminal or lateral eyelets—

for inserting other wires, e.g. for ablation or biopsy, or fiberoptics, or for infusion and/or suction.

17. The use of the electrocatheter as per claim 1, for the single-catheter intracardiac mapping of multiple monophasic action potentials (MAPs), with high spatial resolution (Multi-MAP function).

18. The use of the electrocatheter as per claim 1, by single-catheter percutaneous epicardial mapping of multiple monophasic action potentials (MAPs), with high spatial resolution.

19. The use of the electrocatheter as per claim 1, for the magnetocardiographic localization of the catheter tip.

20. The use of the electrocatheter as per claim 1, for MCG-guided drive of the catheter by numerical spatial control of the distal end thereof, until the three-dimensional coordinates fit at the best those of the arrhythmogenic area where the MAPs recording is to be carried out.

21. The use of the electrocatheter as per claim 1, for the automatic estimate of the local scattering of the repolarization.

22. The use of the electrocatheter as per claim 1, for the automatic estimate of the local conduction speed.

23. The use of the electrocatheter as per claim 1, for the automatic estimate of the route of the local depolarization front.

24. The use of the electrocatheter as per claim 1, for the electroanatomical integration of the aforesaid information with the three-dimensional coordinates of the catheter tip.

25. The use of the electrocatheter as per claim 1, for the output of energy by laser emission.