Process and device for determining the pulse transit time and extracorporeal hemotherapeutic arrangement with such a device

• US 6,527,728 B2
• Filed: 10/19/2001
• Issued: 03/04/2003
• Est. Priority Date: 10/19/2000
• Status: Expired due to Term

• Current Assignee: Fresenius Medical Care Deutschland GmbH (Fresenius SE & Co. KGaA)
• Original Assignee: Fresenius Medical Care Deutschland GmbH (Fresenius SE & Co. KGaA)
• Inventors: Zhang, Wei
• Primary Examiner(s): Hindenburg, Max F.
• Assistant Examiner(s): Natnithithadha, Navin
• Application Number:
  US09/982,238
• Publication Number:
  US 20020055672A1
• Time in Patent Office: 501 Days
• Field of Search: 600/500, 600/310, 600/368, 600/476, 600/479, 600/480, 600/481, 600/485, 600/504
• US Class Current: 600/500
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/02125 of pulse wave propagation time
• CPC Class Codes: A61B 5/0285 Measuring or recording phase velocity of blood waves
• CPC Class Codes: A61B 5/14535 for measuring haematocrit
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/3609 Physical characteristics of the blood, e.g. haematocrit, urea
• CPC Class Codes: A61M 1/367 Circuit parts not covered by the preceding subgroups of group A61M1/3621
• CPC Class Codes: A61M 2205/18 with alarm
• CPC Class Codes: A61M 2205/3344 Measuring or controlling pressure at the body treatment site
• CPC Class Codes: A61M 2205/3375 Acoustical, e.g. ultrasonic, measuring means
• CPC Class Codes: A61M 2230/207 hematocrit
• CPC Class Codes: A61M 2230/30 Blood pressure A61M2230/04 takes precedence

Abstract

A process and a device for improving the determination of the pulse transit time for non-invasive blood pressure measurement. A value, correlating with the blood density, is determined and its influence on the pulse transit time is compensated. In this manner more precise blood pressure data can be obtained. In a further development, a value, correlating with the blood density, is determined by a measuring device for the change in relative blood volume or hematocrit. The device can also be used as part of a hemotherapeutic arrangement such as a hemodialysis device and/or hemofiltration device, in which a blood pressure monitoring as continuous and precise as possible is desired, among other things, because of a blood volume change and thereby a blood density change inherent in the therapy.

Claims

1. A process for determining the pulse transit time of a patient or donor, in which a pulse transit time is measured for pulse waves, propagating via the patient'"'"'s or donor'"'"'s vascular system and created by his/her heart contractions, comprising:

determining a value, correlating with a blood density; and

using the value, correlating with the blood density, to calculate, from the pulse transit time measured, a pulse transit time for which an influence of the blood density is compensated.

2. The process, according to claim 1, wherein the value, correlating with the blood density, is one of a relative blood volume or, respectively, a relative change in blood volume.

3. The process, according to claim 1, wherein the value, correlating with the blood density, represents hematocrit or a relative change in hematocrit.

4. The process, according to claim 2, wherein to determine the value, correlating with the blood density, an ultrasonic runtime measurement is carried out on the blood.

5. The process, according to claim 2, wherein to determine the value, correlating with the blood density, an optical direct light measurement and/or scattered light measurement is carried out on the blood.

6. The process, according to claim 1, wherein a pulse transit time PTT (t),p(t),ρ

(t0)), compensated with respect to the blood density ρ

(t0) at time t0, is determined from a measurement value of the pulse transit time PTT (t,p(t),ρ

(t)) for a time t, for the blood density ρ

(t) present at this point in time and the present blood pressure p(t), according to the following expression;

7. The process, according to claim 6, wherein the relation of the blood densities is determined by the expression

8. The process, according to claim 6, wherein the relation between the blood densities is expressed by the expression

9. A device for determining a patient'"'"'s or donor'"'"'s pulse transit time comprising:

means for determining the pulse transit time of pulse waves, which are propagated via the patient'"'"'s or donor'"'"'s vascular system and are created by heart contractions;

means for determining a value, correlating with blood density; and

an evaluation unit compensating for an influence of the blood density on the pulse transit time.

10. The device, according to claim 9, wherein the means for determining the pulse transit time comprises a unit to provide an electrocardiogram, and the evaluation unit is suitable to determine a first reference point, ta, of the pulse transit time from the electrocardiogram.

11. The device, according to claim 10, wherein the evaluation unit for the first reference point, ta, determines the time at which the R peak appears on the electrocardiogram.

12. The device, according to claim 10, wherein said means for determining the pulse transit time comprise a unit for detecting the pulse waves at a point at a distance from the heart, the evaluation unit being suitable for determining a second reference point, te, of the pulse transit time from the detection of the pulse waves at a point at a distance from the heart.

13. The device, according to claim 12, wherein the unit for detecting the pulse waves at a point at a distance from the heart is a device for detecting the pulse waves at a point on the body, including a finger of the patient or the donor.

14. The device, according to claim 13, wherein the unit for detecting the pulse waves at a point at a distance from the heart is a photoplethysmograph.

15. The device, according to claim 9, wherein the means for determining a value, correlating with the blood density, comprise a measuring device for determining one of the relative blood volume or, respectively, the relative change in blood volume, such that the relative blood volume or, respectively, the relative change in blood volume represent the value, correlates with the blood density.

16. Device, according to claim 9, wherein the means for determining a value, correlating with the blood density, comprise a measuring device for determining the hematocrit or the relative change in hematocrit, such that the hematocrit or, respectively, the relative change in hematocrit represents the value, correlates with the blood density.

17. The device, according to claim 15, wherein the measuring device is an ultrasonic runtime measuring device.

18. The device, according to claim 15, wherein the measuring device is one of an optical direct light measuring device and a scattered light measuring device.

19. The device, according to claim 9, wherein the evaluation unit determines a pulse transit time PTT (t,p(t),ρ

(t0)), compensated with respect to the blood density ρ

(t0) at the time t0, from a measurement value of the pulse transit time PTT (t,p(t),ρ

(t)) for a time t, for the blood density ρ

(t) present at this point in time and the present blood pressure p(t) according to the following expression;

20. The device, according to claim 19, wherein the relation between the blood densities is represented by the expression

21. The device, according to claim 19, wherein the relation between the blood densities is represented by the expression

22. The device, according to claim 9, wherein the device further includes an alarm and the evaluation unit is suitable for recognizing abnormal values of the pulse transit time by means of stored criteria and then setting on the alarm.

23. The device, according to claim 9, wherein the means for determining the pulse transit time comprise the means for determining a value, correlating with the blood density.

24. A hemotherapeutic arrangement with an extracorporeal blood circulation, comprising:

a hemotherapeutic filter arrangement;

a blood supply line for connection to a patient or donor, said supply line being connected at one end to an intake of the hemotherapeutic filter arrangement and connectable at the other end to the patient'"'"'s or donor'"'"'s vascular system;

a blood removal line for connection to the patient or donor, said removal line being connected at one end to an outlet of the hemotherapeutic filter arrangement and connectable at the other end to the patient'"'"'s or donor'"'"'s vascular system; and

a device for determining the patient'"'"'s or donor'"'"'s pulse transit time including,

means for determining the pulse transit time of pulse waves, which are propagated via the patient'"'"'s or donor'"'"'s vascular system and are created by heart contractions;

means for determining a value, correlating with blood density; and

an evaluation unit compensating for an influence of the blood density on the pulse transit time.

25. The hemotherapeutic arrangement according to claim 24, wherein said hemotherapeutic filter arrangement is one of a hemodialyzer and a hemofilter.

26. The hemotherapeutic arrangement according to claim 24, wherein said means for determining the pulse transit time is a unit for detecting the pulse waves at a point at a distance from the heart, said unit including a measuring sensor for detecting a reference point extracorporeally at a point in the extracorporeal blood circulation.

27. The hemotherapeutic arrangement according to claim 26, wherein the measuring sensor is a pressure sensor.

28. The hemotherapeutic arrangement according to claim 24, wherein said means for determining a value, correlating with the blood density, are provided extracorporeally on a point of the extracorporeal blood circulation.

29. The hemotherapeutic arrangement according to claim 28, wherein said means for determining a value includes at least one of an optical direct light sensor and a scattered light sensor.

30. The hemotherapeutic arrangement according to claim 28, wherein said means for determining a value is an ultrasonic runtime sensor.