Reducing noise in a technique for diagnosing attention deficit hyperactivity disorder

• US 6,527,730 B2
• Filed: 12/21/2000
• Issued: 03/04/2003
• Est. Priority Date: 12/21/2000
• Status: Expired due to Fees

• Current Assignee: Mclean Hospital (Mass General Brigham, Inc.)
• Original Assignee: Eastman Kodak Company
• Inventors: Patton, David L., Parks, Peter A., Blazey, Richard N.
• Primary Examiner(s): Hoang, Tu Ba
• Application Number:
  US09/746,052
• Publication Number:
  US 20020112732A1
• Time in Patent Office: 803 Days
• Field of Search: 600/483, 600/484, 600/509, 600/536, 600/544, 600/549, 600/558, 600/545, 600/546, 600/27, 600/300, 600/301, 128/905, 128/897, 128/898, 434/238, 607/9, 424/239.1, 424/197.11, 424/408, 424/448, 424/449
• US Class Current: 600/549
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/168 Evaluating attention deficit, hyperactivity

Abstract

A method of determining whether an individual has Attention Deficit Hyperactivity Disorder (ADHD) comprising: sampling the peripheral skin temperature of a human subject during a predetermined time interval when the subject is in an inactive state to provide a sampled peripheral skin temperature signal containing noise: modulating said sampled peripheral skin temperature signal containing noise with a known reference signal to produce a modulated signal; inputting said modulated signal and said known reference signal to a lock-in amplifier to produce a sampled peripheral skin temperature signal free of said noise; and analyzing the sampled peripheral skin temperature signal for a pre-selected parameter to determine whether said predetermined parameter has a value indicative of ADHD.

Claims

1. A method of determining whether an individual has Attention Deficit Hyperactivity Disorder (ADHD) comprising:

sampling the peripheral skin temperature of a human subject during a predetermined time interval when the subject is in an inactive state to provide a sampled peripheral skin temperature signal containing noise;

modulating said sampled peripheral skin temperature signal containing noise with a known reference signal to produce a modulated signal;

inputting said modulated signal and said known reference signal to a Lock-in amplifier to produce a sampled peripheral skin temperature signal free of said noise; and

analyzing the sampled peripheral skin temperature signal free of said noise for a pre-selected parameter to determine whether said predetermined parameter has a value indicative of ADHD.

2. The method of claim 1 wherein the skin temperature of at least one extremity of a human subject is sampled.

3. The method of claim 1 wherein the skin temperature of at least one finger of a human subject is sampled.

4. The method of claim 1 wherein during said predetermined time interval when said subject is in an inactive state, the subject wears an earphone to block out ambient noise or to receive white noise to reduce or eliminate audio stimulus form the ambient environment during said time interval.

5. The method of claim 1 wherein said signal free of said noise is processed with a fast fourier transform algorithm to produce frequency and phase data and said phase data is used to determine whether the subject has ADHD.

6. The method of claim 5 wherein said frequency and phase data is further to produce magnitude range data which is used to determine whether the subject has ADHD.

7. A system for determining whether an individual has ADHD comprising:

a device for sampling the peripheral skin temperature of a human subject during a predetermined time interval when the subject is in an inactive state to provide sampled peripheral skin temperature signal containing noise;

a source of a known reference signal;

a modulator for modulating said sampled peripheral skin temperature signal containing noise with said known reference signal from said source to produce a modulated signal;

a lock-in amplifier which receives at its input said modulated signal and said known reference signal and which outputs a sampled peripheral skin temperature signal free of said noise; and

an analyzer for analyzing said sampled peripheral skin temperature signal free of said noise for a pre-selected parameter to determine whether said pre-selected parameter has a value indicative of ADHD.

8. The system of claim 7 wherein said device includes a sensor for sensing the skin temperature of at least one extremity of a human subject.

9. The method of claim 7 wherein said device includes a sensor for sensing the skin temperature of at least one finger of a human subject.

10. The method of claim 7 including an earphone worn by the subject during said predetermined time interval to block out ambient noise or to receive white noise to reduce or eliminate audio stimulus from the ambient environment during said time interval.

11. The method of claim 10 including a source of white noise coupled to said earphone to provide white noise during said predetermined time interval.