Method of peritoneal dialysis

• US 6,527,735 B1
• Filed: 04/27/2000
• Issued: 03/04/2003
• Est. Priority Date: 04/27/2000
• Status: Expired due to Term

• Current Assignee: Cytosorbents Corporation
• Original Assignee: RenalTech International LLC
• Inventors: Brady, James, Levin, Nathan, Davankov, Vadim
• Primary Examiner(s): FOX, JOHN C
• Application Number:
  US09/560,312
• Time in Patent Office: 1,041 Days
• Field of Search: 604/29, 604/5.04, 604/6.09
• US Class Current: 604/29
• CPC Class Codes: A61M 1/1696 with dialysate regeneration
• CPC Class Codes: A61M 1/28 Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
• CPC Class Codes: A61M 1/287 Dialysates therefor
• CPC Class Codes: A61M 1/3479 by dialysing the filtrate
• CPC Class Codes: A61M 1/3486 Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
• CPC Class Codes: B01J 20/26 Synthetic macromolecular compounds
• CPC Class Codes: B01J 20/261 obtained by reactions only involving carbon to carbon unsaturated bonds macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds per se C08F
• CPC Class Codes: B01J 20/267 Cross-linked polymers
• CPC Class Codes: B01J 20/28078 Pore diameter
• CPC Class Codes: B01J 20/28083 being in the range 2-50 nm, i.e. mesopores
• CPC Class Codes: B01J 20/28095 Shape or type of pores, voids, channels, ducts

Abstract

A method of peritoneal dialysis includes introducing a dialysis solution into a peritoneal cavity; allowing the dialysis solution to dwell in the peritoneal cavity for a period of time to provide diffusion through an inner lining of an abdominal cavity with exchange of components between a microcirculation of a peritoneum and a dialysis fluid; withdrawing the dialysis solution from the peritoneal cavity with toxins; passing the dialysis solution with toxins through an absorbent polymeric material which has a size, shape, and structure selected so as to remove the toxins in a molecular range of 300-30,000 Dalton from the spent dialysis solution; and returning the thusly purified peritoneal dialysis solution to the patient.

Claims

1. A method of peritoneal dialysis, comprising the steps of introducing a dialysis solution into a peritoneal cavity;

allowing the dialysis solution to dwell in the peritoneal cavity for a period of time to provide diffusion through an inner lining of an abdominal cavity with exchange of components between a microcirculation of a peritoneum and the dialysis solution;

then withdrawing the dialysis solution from the peritoneal cavity with toxins;

passing the dialysis solution with toxins through an adsorbent porous hydrophobic polymeric material composed of beads with pores which has a size, shape, and structure selected so as to remove the toxicants in a molecular range of 300-30,000 Dalton from the dialysis solution; and

returning the thusly purified peritoneal dialysis solution to the patient.

2. A method as defined in claim 1, wherein said adsorbent porous hydrophobic polymeric material has an enhanced proportion of pores in a diameter range between 1 and 10 nm.

3. A method as defined in claim 2, wherein said porous hydrophobic polymeric material includes a copolymer of a crosslinking divinyl compound selected from the group consisting of divinylbenzene and diisopropenylbenzene and a monovinyl compound selected from the group consisting of styrene, ethylstyrene, alkyl acrylate and acrylo nitrile.

4. A method as defined in claim 2, wherein said porous hydrophobic polymeric material includes a hypercrosslinked polystyrene prepared by post-crosslinking of a macroporous styrene-divinylbenzene copolymer swollen in a solvent.