Ultrasound assembly for use with light activated drugs

• US 6,527,759 B1
• Filed: 07/20/2000
• Issued: 03/04/2003
• Est. Priority Date: 03/08/1995
• Status: Expired due to Term

• Current Assignee: EKOS Corporation (Boston Scientific Corporation)
• Original Assignee: EKOS Corporation (Boston Scientific Corporation)
• Inventors: Anderson, James R., Lichttenegger, Gary, Tachibana, Katsuro, Tachibana, Shunro
• Primary Examiner(s): Bockelman, Mark
• Application Number:
  US09/620,701
• Time in Patent Office: 957 Days
• Field of Search: 604/21-22, 604/500, 604/101.01, 604/101.03, 604/507-509, 604/522, 607/97, 601/2, 601/3, 514/410, 514/145
• US Class Current: 604/500
• CPC Class Codes: A61B 17/2202 the ultrasound transducer being inside patient's body at the distal end of the catheter
• CPC Class Codes: A61B 2017/00853 low friction, hydrophobic and corrosion-resistant fluorocarbon resin coating (ptf, ptfe, polytetrafluoroethylene)
• CPC Class Codes: A61B 2017/22002 preventing restenosis
• CPC Class Codes: A61B 2017/22021 electric leads passing through the catheter
• CPC Class Codes: A61B 2017/22062 to be filled with liquid
• CPC Class Codes: A61B 2017/22088 ultrasound absorbing, drug activated by ultrasound
• CPC Class Codes: A61K 41/0047 Sonopheresis, i.e. ultrasonically-enhanced transdermal delivery, electroporation of a pharmacologically active agent
• CPC Class Codes: A61M 37/0092 using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092

Abstract

A kit and method for causing tissue death within a tissue site is disclosed. The kit includes a media with a light activated drug activatable upon exposure to a particular level of ultrasound energy. The kit also includes a catheter with a lumen coupled with a media delivery port through which the light activated drug can be locally delivered to the tissue site. The ultrasound transducer is configured to transmit the level of ultrasound energy which activates the light activated drug with sufficient power that the ultrasound energy can penetrate the tissue site.

Claims

1. A method for treating a subdermal tissue site, comprising:

providing a catheter for locally delivering a light activated drug to the subdermal tissue site, the catheter including an ultrasound transducer;

placing the catheter into the body near the tissue site;

locally delivering the light activated drug to the tissue site;

producing ultrasound energy from the ultrasound transducer; and

directing the ultrasound energy to the subdermal tissue site following delivery of the light activated drug to the subdermal tissue site to activate at least a portion of the light activated drug.

2. The method of claim 1, further comprising directing ultrasound energy to the tissue site to enhance absorption of the light activated drug into the tissue site prior to activation of the light activated drug.

3. The method of claim 1, wherein directing the ultrasound energy to the subdermal tissue site includes positioning the ultrasound transducer adjacent the subdermal tissue site.

4. The method of claim 1, wherein the tissue site is selected from a group consisting of an atheroma and a tumor.

5. The method of claim 1, wherein locally delivering the light activated drug includes positioning a media delivery port included on the catheter adjacent the tissue site and delivering the media through the media port via the lumen in a catheter.

6. The method of claim 1, wherein locally delivering the light activated drug includes locally delivering a media with microbubbles.

7. The method of claim 6, wherein the microbubbles are liposomes.

8. The method of claim 1, wherein locally delivering the light activated drug includes locally delivering an emulsion with a lipoid as a hydrophobic phase dispersed in a hydrophylic phase.

9. The method of claim 1, wherein locally delivering the light activated drug includes locally delivering a site directing molecule coupled with the light activated drug, the site directing molecule having an affinity for an element of the tissue site.

10. The method of claim 9, wherein the site directing molecule is an oligonucleotide.

11. The method of claim 1, wherein the light activated drug is selected from the group consisting of GdT2BET, LuT2BET, SnEt₂ and T2B1 TXP Metal Complex-Oligonucleotide Conjugate.

12. The method of claim 1, wherein the light activated drug is selected from the group including photoreactive pyrrole-derived macrocycles and expanded pyrrole-based macrocycles.

13. The method of claim 1, wherein the light activated drug is selected from the group consisting of porphyrins, chlorins, bacteriochlorins, isobateriochlorins, phthalocyanines, naphtalocyanines, porphycenes, sapphyrins, texaphyrins, derivatives of porphyrins, derivatives of chlorins, derivatives of bacteriochlorins, derivatives of isobateriochlorins, derivatives of phthalocyanines, derivatives of naphtalocyanines, derivatives of porphycenes, derivatives of sapphyrins and derivatives of texaphyrins.

14. The method of claim 1, wherein the light activated drug includes a green porphyrin.

15. A method for activating a light activated drug, comprising:

providing a catheter including an ultrasound transducer;

placing the catheter into the body near the tissue site;

introducing the light activated drug into a patient'"'"'s body, wherein a subdermal tissue site absorbs at least a portion of the light activated drug;

producing ultrasound energy;

directing the ultrasound energy from said ultrasound transducer to the subdermal tissue site including the light activated drug; and

activating at least a portion of the light activated drug in the subdermal selected tissue site.

16. The method of claim 15, wherein the ultrasound transducer is positioned to direct ultrasound energy into a wall of a blood vessel.

17. The method of claim 15, wherein a distal portion of the catheter is positioned in a patient'"'"'s circulatory system.

18. The method of claim 15, wherein a distal portion of the catheter is positioned in a patient'"'"'s blood vessel.

19. The method of claim 15, wherein the transducer is positioned to direct ultrasound energy in a lateral direction relative to a longitudinal axis of the catheter.

20. The method of claim 15, wherein the ultrasound transducer is positioned in an interior of the patient'"'"'s body.

21. The method of claim 15, wherein the ultrasound transducer is positioned in an interior of a blood vessel.

22. The method of claim 15, wherein the ultrasound transducer is positioned adjacent to an atheroma.

23. The method of claim 15, wherein the ultrasound transducer is positioned adjacent to a tumor.

24. The method of claim 15, further comprising providing a temperature sensor on the catheter and measuring a temperature adjacent to the ultrasound transducer for adjusting a level of the ultrasound energy in response to the temperature.

25. A method for preventing restenosis, comprising:

providing an elongate catheter having a drug delivery lumen and an ultrasound transducer mounted along a distal end portion;

advancing the catheter through a patient'"'"'s vasculature such that the distal end portion is located along a treatment site in a blood vessel;

locally delivering an emulsion containing a light activated drug through the drug delivery lumen to the treatment site; and

directing ultrasound energy from said ultrasound transducer along the treatment site to activate at least a portion of the light activated drug.

26. The method of claim 25, wherein the emulsion containing a light activated drug further comprises a plurality of microbubbles.

27. The method of claim 25, wherein the ultrasound energy is directed along the treatment site at about 0.3 W/cm² at a frequency of about 1.3 MHz for about 10 minutes.

28. The method of claim 25, further comprising providing a temperature sensor along the distal end portion of the catheter and measuring a temperature adjacent to the ultrasound transducer for adjusting a level of the ultrasound energy in response to the temperature.