Methods and devices for obstructing and aspirating lung tissue segments
First Claim
1. A method for lung volume reduction, said method comprising:
- deploying an obstructive device in a lung passageway to a lung tissue segment; and
aspirating the segment through the deployed obstructive device to at least partially collapse the lung segment.
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0 Petitions
Accused Products
Abstract
Methods, systems, devices and kits for performing lung volume reduction in patients suffering from chronic obstructive pulmonary disease or other conditions using and comprising minimally invasive instruments introduced through the mouth (endotracheally) to isolate a target lung tissue segment from other regions of the lung and reduce lung volume. Isolation is achieved by deploying an obstructive device in a lung passageway leading to the target lung tissue segment. Once the obstructive device is anchored in place, the segment can be aspirated through the device. This may be achieved by a number of methods, including coupling an aspiration catheter to an inlet port on the obstruction device and aspirating through the port. Or, providing the port with a valve which allows outflow of gas from the isolated lung tissue segment during expiration of the respiratory cycle but prevents inflow of air during inspiration. In addition, a number of other methods may be used. The obstructive device may remain as an implant, to maintain isolation and optionally allow subsequent aspiration, or the device maybe removed at any time.
539 Citations
68 Claims
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1. A method for lung volume reduction, said method comprising:
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deploying an obstructive device in a lung passageway to a lung tissue segment; and
aspirating the segment through the deployed obstructive device to at least partially collapse the lung segment. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
advancing an aspiration catheter into the lung passageway toward the obstructive device, wherein the aspiration catheter has an occlusion balloon near its distal end;
inflating the occlusion balloon to substantially occlude the lung passageway proximal to the obstructive device; and
aspirating gas through the obstructive device and the catheter.
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8. A method as in claim 7, wherein the obstructive device comprises a valve and aspirating opens the valve.
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9. A method as in claim 8, wherein the valve comprises a port and engaging comprises sliding a coupling member or the aspiration catheter over the port to form a seal.
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10. A method as in any of claims 1, 3 or 6, wherein the obstructive device comprises a structural support and deploying comprises expanding the structural support so that it anchors in the passageway.
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11. A method as in claim 10, wherein the structural support comprises a self-expanding support and expanding comprises releasing the self-expanding support from constraint so that it expands and thereby anchors in the passageway.
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12. A method as in claim 11, wherein deploying further comprises inflating a balloon which expands the structural support.
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13. A method as in claim 1, further comprising positioning an access catheter in the lung passageway prior to deployment of the obstruction device, said access catheter having a proximal end, a distal end, and at least one lumen extending therethrough.
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14. A method as in claim 13, wherein the access catheter has an occlusion balloon near its distal end and aspirating comprises:
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inflating the occlusion balloon to substantially occlude the lung passageway proximal to the obstructive device; and
aspirating gas through the obstructive device and the catheter.
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15. A method as in claim 14, wherein the access catheter provides optical imaging.
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16. A method as in claim 14, wherein the access catheter is steerable.
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17. A method as in claim 14, wherein the access catheter is positioned with the use of a guidewire.
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18. A method as in claim 17, wherein the guidewire provides imaging capabilities.
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19. A method as in claim 1, further comprising introducing a gas or liquid to the segment prior to aspiration.
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20. A method as in claim 19, wherein the gas comprises 100% oxygen, a Helium-Oxygen mixture or a low molecular weight gas.
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21. A method as in claim 19, wherein the liquid comprises perfluorocarbon or a drug.
- 22. A method for lung volume reduction, said method comprising deploying a unidirectional valve within a lung passageway to a lung tissue segment, wherein the valve opens during expiration to allow outflow of gas from the lung segment and the valve closes during inspiration to prevent inflow of gas to the lung segment.
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32. A method for lung volume reduction, said method comprising:
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accessing a lung passageway to a lung tissue segment; and
deploying a blockage device in the passageway. - View Dependent Claims (33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47)
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48. A device for obstructing and bleeding gas from a lung tissue segment, said device comprising:
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an expandable structure which is deployable within a lung passageway; and
means for the expandable structure for blocking airflow in one direction therethrough and permitting airflow in the other direction therethrough. - View Dependent Claims (49, 50, 51, 52, 53, 54, 55, 56)
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57. A system for obstructing a lung passageway to a lung tissue segment, said system comprising:
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an access catheter having a proximal end, a distal end, and at least one lumen extending therethrough, and an obstruction device deployable within the lung passageway having an inlet port adapted for aspirating the lung tissue segment through the inlet port, wherein the obstruction device is introduceable by the access catheter. - View Dependent Claims (58, 59)
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60. A kit comprising:
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an obstruction device deployable within a lung passageway; and
instructions for use according to a method of lung volume reduction comprising;
deploying an obstructive device in a lung passageway to a lung tissue segment; and
aspirating the segment through the deployed obstructive device to at least partially collapse the lung segment. - View Dependent Claims (61, 62, 63, 64, 65, 66)
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67. A kit comprising:
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an obstruction device deployable within the lung passageway; and
instructions for use according to a method of lung volume reduction comprising deploying a unidirectional valve within a lung passageway to a lung tissue segment, wherein the valve opens during expiration to allow outflow of gas from the lung segment and the valve closes during inspiration to prevent inflow of gas to the lung segment.
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68. A kit comprising:
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an obstruction device deployable within the lung passageway; and
instructions for use according to a method of lung volume reduction comprising;
accessing a lung passageway to a lung tissue segment; and
deploying a blockage device in the passageway.
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Specification