Catheter systems and methods for their use in the treatment of calcified vascular occlusions

• US 6,527,979 B2
• Filed: 08/27/1999
• Issued: 03/04/2003
• Est. Priority Date: 08/27/1999
• Status: Expired due to Term

• Current Assignee: Cardinal Health Switzerland 515 GmbH (Cardinal Health, Inc.)
• Original Assignee: Corazon Technologies, Inc. (Cardinal Health, Inc.)
• Inventors: McGurk, Erin, Johansson, Peter K., Constantz, Brent R.
• Primary Examiner(s): Casler, Brian L.
• Assistant Examiner(s): Thissell, Jeremy
• Application Number:
  US09/384,860
• Publication Number:
  US 20020044907A1
• Time in Patent Office: 1,285 Days
• Field of Search: 604/500, 604/523, 604/96.01, 604/508, 423/481, 424/666, 424/663, 424/680, 436/18, 252/364, 206/438
• US Class Current: 252/364
• CPC Class Codes: A61M 2025/0004 having two or more concentrically arranged tubes for forming a concentric catheter system
• CPC Class Codes: A61M 2025/1052 for temporarily occluding a vessel for isolating a sector
• CPC Class Codes: A61M 2025/1095 with perfusion means for enabling blood circulation while the balloon is in an inflated state or in a deflated state, e.g. permanent by-pass within catheter shaft
• CPC Class Codes: A61M 25/0026 Multi-lumen catheters with stationary elements catheter assemblies comprising a catheter in combination with a guide tube, sheath or sleeve A61M2025/0681; catheters comprising telescoping coaxial elements A61M2025/0175
• CPC Class Codes: A61M 25/1011 Multiple balloon catheters
• CPC Class Codes: A61M 29/02 Dilators made of swellable material balloon catheters for angioplasty A61M25/104

Abstract

Catheter systems and methods for their use in enhancing fluid flow through a vascular site occupied by a vascular occlusion are provided. The subject catheter systems include at least an aspiration catheter and at least one of a total occlusion insert catheter and a partial occlusion insert catheter, where the insert catheters are capable of being slidably moved in the lumen of the aspiration catheter. In practicing the subject methods, a surface of the vascular occlusion is flushed with an acidic dissolution fluid using the subject catheter systems for a period of time sufficient for fluid flow through the vascular site to be enhanced, e.g. increased or established. The subject catheter systems and methods find use in the treatment of a variety of different vascular diseases characterized by the presence of calcified vascular occlusions, including peripheral and coronary vascular diseases.

Claims

1. An aqueous acidic dissolution fluid consisting essentially of:

hydrogen chloride in a concentration ranging from about 0.01 to 1.0 N; and

a salt in a concentration ranging from 0.05 to 0.25 M.

2. The solution according to claim 1, wherein said salt is NaCl.

3. The solution according to claim 2, wherein said NaCl is present in a concentration ranging from about 0.05 to 0.1 M.

4. An aqueous acidic dissolution fluid consisting essentially of:

hydrogen chloride in a concentration ranging from about 0.01 to 1.0 N; and

NaCl in a concentration ranging from 0.05 to 0.25 M.

5. The solution according to claim 4, wherein said hydrogen chloride is present in a concentration ranging from about 0.05 to 0.5N.

6. The solution according to claim 5, wherein said hydrogen chloride is present in an amount ranging from about 0.075 to about 0.25 N.

7. The solution according to claim 4, wherein said NaCl is present in an amount ranging from 0.05 to 0.10 M.

8. An aqueous acidic dissolution fluid consisting essentially of:

hydrogen chloride in a concentration ranging from about 0.05 to 0.5N; and

NaCl in a concentration ranging from 0.05 to 0.10 M.

9. An aqueous acidic dissolution fluid consisting essentially of:

hydrogen chloride in a concentration ranging from about 0.075 to about 0.25 N; and

NaCl in a concentration ranging from.0.05 to 0.10 M.

10. A kit for use in enhancing fluid flow through a vascular site occupied by a vascular occlusion, said kit comprising:

(a) an aqueous acidic dissolution fluid consisting essentially of;

(i) hydrogen chloride in a concentration ranging from about 0.01 to 1.0N; and

(ii) a salt in a concentration ranging from 0.05 to 0.25 M; and

(b) instructions for using said aqueous acidic dissolution fluid to enhance fluid flow through a vascular site occupied by a vascular occlusion.

11. The kit according to claim 10, wherein said salt is NaCl.

12. The kit according to claim 11, wherein said NaCl is present in a concentration ranging from 0.05 to 0.1 M.

13. A kit for use in enhancing fluid flow through a vascular site occupied by a vascular occlusion, said kit comprising:

(a) an aqueous acidic dissolution fluid consisting essentially of;

(i) hydrogen chloride in a concentration ranging from about 0.01 to 1.0N; and

(ii) NaCl in a concentration ranging from 0.05 to 0.25 M; and

(b) instructions for using said aqueous acidic dissolution fluid to enhance fluid flow through a vascular site occupied by a vascular occlusion.

14. The kit according to claim 13, wherein said hydrogen chloride is present in a concentration ranging from about 0.05 to 0.5N.

15. The kit according to claim 14, wherein said hydrogen chloride is present in an amount ranging from about 0.075 to about 0.25 N.

16. The kit according to claim 13, wherein said NaCl is present in an amount ranging from 0.05 to 0.10 M.

17. A kit for use in enhancing fluid flow through a vascular site occupied by a vascular occlusion, said kit comprising:

(a) an aqueous acidic dissolution fluid consisting essentially of;

(i) hydrogen chloride in a concentration ranging from about 0.01 to 1.0N; and

(ii) a salt in a concentration ranging from 0.05 to 0.25 M;

(b) a catheter; and

(c) instructions for using said aqueous acidic dissolution fluid to enhance fluid flow through a vascular site occupied by a vascular occlusion.

18. The kit according to claim 17, wherein said salt is NaCl.