EMU oil-based formulations for use as an analgesic, anesthetic and antipruritic

• US 6,528,040 B1
• Filed: 08/24/2001
• Issued: 03/04/2003
• Est. Priority Date: 01/18/2001
• Status: Expired due to Term

• Current Assignee: Ntech Health And Wellness, LLC
• Original Assignee: Maurine Pearson
• Inventors: Pearson, Maurine, Barr, Teresa L.
• Primary Examiner(s): Naff, David M.
• Assistant Examiner(s): Ware, Deborah K.
• Application Number:
  US09/939,335
• Time in Patent Office: 557 Days
• Field of Search: 424/70.1, 424/520, 424/522, 424/93.1, 424/93.7, 424/192.1, 424/198, 424/43, 424/400, 435/325, 514/104
• US Class Current: 424/43
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/05 Phenols cannabinoids A61K31/658
• CPC Class Codes: A61K 31/201 having one or two double bonds, e.g. oleic, linoleic acids
• CPC Class Codes: A61K 31/202 having three or more double bonds, e.g. linolenic eicosanoids, e.g. leukotrienes A61K31/557
• CPC Class Codes: A61K 31/216 of acids having aromatic rings, e.g. benactizyne, clofibrate
• CPC Class Codes: A61K 31/4166 having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
• CPC Class Codes: A61K 31/66 Phosphorus compounds
• CPC Class Codes: A61K 35/57 Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
• CPC Class Codes: A61K 47/10 Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/12 Aerosols; Foams A61K9/0043, A61K9/0056, A61K9/006, A61K9/0073 take precedence; spray-films A61K9/7015
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 17/04 Antipruritics
• CPC Class Codes: A61P 23/02 Local anaesthetics
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

An analgesic, anesthetic and antipruritic formulation is provided containing 0.01 to 13 wt % alkyl esters; and 20 to 70 wt % Emu oil; 10 to 33 wt % benzyl alcohol; 10 to 33 wt % benzoin; 0.2 to 2 wt % allantoin; 0.25 to 1.25 wt % methylparaben and 0.01 to 0.30 wt % propylparaben. The formulation may be formulated as a spray or transdermal formula. The formulation may be used for treatment of chronic cutaneous ulcers and burn wounds.

Claims

1. An analgesic, anesthetic and antipruritic formulation comprising:

0.01 to 13 wt % alkyl esters;

20 to 70 wt. % Emu oil;

10 to 33 wt % benzyl alcohol;

10 to 33 wt % benzoin;

0.2 to 2 wt % allantoin

0.25 to 1.25 wt % methylparaben; and

0.01 to 0.30 wt % propylparaben.

2. The formulation of claim 1, comprising 60-65 wt % refined and sterilized Emu oil.

3. The formulation of claim 2, wherein said refined and sterilized Emu oil comprises at least 70 wt % linoleic and linolenic acids in combination.

4. The formulation of claim 3, wherein said formulation comprises 20 wt % linoleic and 1-2 wt % linolenic acid.

5. The formulation of claim 1, comprising 10 to 20 wt % benzyl alcohol.

6. The formulation of claim 1, wherein said benzyl alcohol is selected from the group consisting of NF Benzenemethanol, phenyl carbinol CH₂OH, and Benzyl C₇H₈.

7. The formulation of claim 1, wherein said formulation is a topical treatment for the epidermis.

8. The formulation of claim 1, wherein said formulation can be applied to horses and humans.

9. The formulation of claim 1, further comprising a member selected from the group consisting of a germicide, a bacteriacide, an antiseptic, an antifungal, a bacteriastatic agent and combinations thereof.

10. The formulation of claim 1 prepared in the form of a gel, a lotion, a spray, a patch or an enhanced oil.

11. An analgesic, anesthetic and antipruritic spray-on transdermal formula comprising:

0.01 to 13 wt % alkyl esters;

20 to 70 wt % refined and sterilized Emu oil;

10 to 33 wt % benzyl alcohol;

10 to 33 wt % benzoin;

0.2 to 2 wt % allantoin;

0.25 to 1.25 wt % methylparaben;

0.01 to 0.30 wt % propylparaben; and

sufficient and effective amounts of environmentally safe propellants.