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Sustained release non-steroidal, anti-inflammatory and lidocaine PLGA microspheres

  • US 6,528,097 B1
  • Filed: 11/20/2000
  • Issued: 03/04/2003
  • Est. Priority Date: 03/16/1984
  • Status: Expired due to Fees
First Claim
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1. A process for preparing controlled release microcapsule formulations characterized by burst-free, sustained, programmable release of non-steroidal, antiinflammatory drugs comprising:

  • dissolving a non-steroidal, antiinflammatory drug and a mixture of uncapped biocompatible, biodegradable poly (lactide/glycolide) polymer and end-capped biocompatible, biodegradable poly (lactide/glycolide) polymer in a volatile organic solvent, dispersing the dissolved mixture in an aqueous phase containing an emulsion stabilizer, and evaporating the organic solvent phase to obtain non-steroidal antiinflammatory drug-loaded microspheres.

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