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Opposable-element chromatographic assay device for detection of analytes in whole blood samples

  • US 6,528,321 B1
  • Filed: 06/26/2000
  • Issued: 03/04/2003
  • Est. Priority Date: 06/26/2000
  • Status: Expired due to Fees
First Claim
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1. A chromatographic assay device for detection of at least one analyte in at least one sample, comprising:

  • (a) a first opposable component including;

    (i) at least one sample application zone each containing a matrix of a porous material permeable to the liquid portion of blood but capable of trapping the cellular components of blood; and

    (ii) at least one chromatographic medium each having a first end in operable contact with a corresponding sample application zone and a second end, each chromatographic medium including;

    (A) a detection zone containing an immobilized first reagent; and

    (B) a conjugate zone located between the first end and the detection zone and containing a labeled second reagent in a resolubilizable form; and

    (b) a second opposable component including;

    (i) at least one applicator each corresponding to a sample application zone for applying a wash liquid; and

    (ii) at least one absorber each corresponding to a chromatographic medium;

    wherein when the first and second opposable components are brought into opposition, each applicator is in operable contact with the corresponding sample application zone to apply the wash liquid in the applicator to the sample application zone, and each absorber is in operable contact with the second end of the corresponding chromatographic medium.

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