Viscosity enhanced ophthalmic solution, having a detergent action on contact lenses

• US 6,528,465 B1
• Filed: 09/25/2001
• Issued: 03/04/2003
• Est. Priority Date: 04/02/1999
• Status: Expired due to Term

• Current Assignee: Laboratoire Medidom Sa
• Original Assignee: Laboratoire Medidom Sa
• Inventors: Cantoro, Amalio
• Primary Examiner(s): DELCOTTO, GREGORY R
• Application Number:
  US09/937,513
• Time in Patent Office: 525 Days
• Field of Search: 510/112, 510/421, 510/434, 510/488, 510/510, 134/42, 514/912
• US Class Current: 510/112
• CPC Class Codes: C11D 1/008 Polymeric surface-active agents
• CPC Class Codes: C11D 1/66 Non-ionic compounds C11D1/002, C11D1/004, C11D1/008 take precedence
• CPC Class Codes: C11D 3/0078 Compositions for cleaning contact lenses, spectacles or lenses
• CPC Class Codes: C11D 3/228 with phosphorus- or sulfur-containing groups
• CPC Class Codes: C11D 3/3707 Polyethers, e.g. polyalkyleneoxides

Abstract

An ophthalmic solution with viscosity enhancing and detergent properties for contact lenses, comprising one or more physiologically acceptably viscosity enhancing agents in aqueous solution having a non-Newtonian rheological behaviour, and one or more physiologically acceptable non-ionic surfactants. The non-ionic surfactant may be selected among esters of fatty acids, sorbitan polyoxyethylates (i.e. polysorbates, such as “Tween”), or block copolymers polyoxyethylene-polyoxypropylene (i.e. poloxamers, such as “Pluronic”). The viscosity enhancing agent may be selected among hyaluronic acid or its salts with alkali or alkaline-earth metals, ethers or esters of cellulose, chitosans, gellans, alginates or carboxyvinyl polymers of the kind Carbopolol® (or carbomer).

Claims

1. An ophthalmic solution with viscoscity enhancing and detergent properties for contact lenses, comprising one or more physiologically acceptable viscosity enhancing agents in aqueous solution having a non-Newtonian rheological behaviour, and one or more physiologically acceptable non-ionic surfactants, wherein the viscosity enhancing agent is hyaluronic acid, or its salts with alkali or alkaline earth metals, and the non-ionic surfactant is poloxamer.

2. An ophthalmic solution according to claim 1, further comprising one or more tonicity adjusting agents.

3. An ophthalmic solution according to claim 1, further comprising one or more buffers.

4. An ophthalmic solution according to claim 1, comprising from 0.005% to 0.50% in weight of sodium hyaluronate and from 0.010% to 2.0% in weight of said poloxamer.

5. An ophthalmic solution according to claim 4, containing the following ingredients in the quantities shown (weight percentages):

6. A process for cleansing contact lenses during their use, which comprises applying on the ocular surface an ophthalmic preparation comprising one or more physiologically acceptable viscosity enhancing agents in aqueous solution having a non-Newtonian rheological behaviour and one or more physiologically acceptable nonionic surfactants, wherein the viscosity enhancing agents is hyaluronic acid or its salts with alkali or alkaline-earth metals and the non-ionic surfactant is poloxamer.

7. A process according to claim 6, wherein said ophthalmic preparation further contains one or more agents for the adjustment of tonicity and one or more buffers.

8. A process according to claim 6, wherein said ophthalmic preparation contains sodium hyaluronate as viscosity enhancing agent.

9. A process according to claim 8 wherein said ophthalmic preparation comprises from 0.005% to 0.50% in weight of sodium hyaluronate and from 0.010% to 2.0% in weight of poloxamer.