Method of treatment with a combination of a PDE4 inhibitor and a leukotriene antagonist

• US 6,528,527 B2
• Filed: 11/02/2001
• Issued: 03/04/2003
• Est. Priority Date: 11/07/2000
• Status: Expired due to Fees

• Current Assignee: Merck Sharp & Dohme Corporation (Merck & Co., Inc.)
• Original Assignee: Merck & Co., Inc.
• Inventors: Chang, Yujun
• Primary Examiner(s): HENLEY III, RAYMOND J
• Application Number:
  US10/003,614
• Publication Number:
  US 20020055520A1
• Time in Patent Office: 487 Days
• Field of Search: 514/352, 514/311
• US Class Current: 514/311
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/44 Non condensed pyridines; Hydrogenated derivatives thereof
• CPC Class Codes: A61K 31/47 Quinolines; Isoquinolines

Abstract

Bronchial and respiratory disorders are treated by the separate, sequential, or simultaneous administration of i) an amount of N-(3,5-dichloropyrid-4-yl)-cyclopropylmethoxy-4-difluoromethoxybenzamide, the pyridyl N-oxide thereof, or a pharmaceutically acceptable salt of either compound; and ii) an amount of a leukotriene antagonist, wherein the sum of the first and second amounts is a therapeutically effective amount.

Claims

1. (Amended) A composition comprising a synergistic combination of i) N-(3,5-dichloropyrid-4-yl)-cyclopropylmethoxy-4-difluoromethoxybenzamide, the pyridyl N-oxide thereof, or a pharmaceutically acceptable salt of either compound;

and ii) a leukotriene antagonist.

2. The composition according to claim 1 wherein said leukotriene antagonist is [R-(E)]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)-phenyl]propyl]thio]methyl]cyclopropaneacetic acid or a pharmaceutically acceptable salt thereof.

3. The composition according to claim 2 wherein said leukotriene is [R-(E)]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)-phenyl]propyl]thio]methyl]cyclopropaneacetic acid, monosodium salt.

4. A method of treatment of bronchial and respiratory disorders comprising:

administering a therapeutically effective amount of a composition according to claim 1.

5. A method of treatment according to claim 4 wherein said disorders are asthma and COPD.

6. (Amended) A method of treatment of bronchial and respiratory disorders comprising the separate, sequential, or simultaneous administration of i) a first amount of N-(3,5-dichloropyrid-4-yl)-cyclopropylmethoxy-4-difluoromethoxybenzamide, the pyridyl N-oxide thereof, or a pharmaceutically acceptable salt of either compound;

and ii) a second amount of a leukotriene antagonist, wherein the sum of the first and second amounts is a therapeutically synergistic effective amount.