Modulated release from biocompatible polymers
First Claim
1. A composition for the modulated release of a prophylactic, therapeutic, or diagnostic agent, comprising:
- a) a biocompatible and biodegradable polymeric matrix;
b) an effective amount of a prophylactic, therapeutic, or diagnostic agent dispersed within the polymeric matrix; and
c) at least one metal monovalent cation for modulating release of the agent from the polymeric matrix, wherein the monovalent cation is obtained from a water-soluble salt and is separately dispersed within the polymeric matrix in the form of particles having a size less than 100 μ
m, wherein the cation is dispersed in a form and amount effective to swell the polymeric matrix and to provide a defined pattern of release of the agent from the matrix over a period of time between one day and nine months, when the matrix is placed in an aqueous solution.
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Accused Products
Abstract
Sustained delivery compositions which modulate the release of incorporated prophylactic, therapeutic, and/or diagnostic agents, and methods of preparation and use thereof, are disclosed. The compositions include a biocompatible polymeric matrix; a prophylactic, therapeutic, and/or diagnostic agent dispersed within the polymeric matrix; and a monovalent cation component which is separately dispersed within the polymeric matrix. The monovalent cation component modulates the release of the incorporated agent from the polymeric matrix. The compositions can be prepared by dissolving a biocompatible polymer in a solvent to form a polymer solution, and separately dispersing a monovalent cation and a prophylactic, therapeutic, and/or diagnostic agent within the polymer solution. The polymer solution is then solidified to form a polymeric matrix, wherein a significant amount of the monovalent cations is dispersed in the polymeric matrix separately from the incorporated agent. The cation modulates the release of the incorporated agent from the polymeric matrix.
74 Citations
19 Claims
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1. A composition for the modulated release of a prophylactic, therapeutic, or diagnostic agent, comprising:
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a) a biocompatible and biodegradable polymeric matrix;
b) an effective amount of a prophylactic, therapeutic, or diagnostic agent dispersed within the polymeric matrix; and
c) at least one metal monovalent cation for modulating release of the agent from the polymeric matrix, wherein the monovalent cation is obtained from a water-soluble salt and is separately dispersed within the polymeric matrix in the form of particles having a size less than 100 μ
m,wherein the cation is dispersed in a form and amount effective to swell the polymeric matrix and to provide a defined pattern of release of the agent from the matrix over a period of time between one day and nine months, when the matrix is placed in an aqueous solution. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 16, 17, 18, 19)
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11. A composition for the modulated release of a biologically active agent, comprising:
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a) a biocompatible polymeric matrix of a poly(lactide-co-glycolide) polymer;
b) an effective amount of a biologically active agent dispersed within the polymeric matrix; and
c) a monovalent cation component for modulating release of the biologically active agent from the polymeric matrix, wherein the monovalent cation component is separately dispersed within the polymeric matrix in the form of particles having a size less than 100 μ
m,wherein the cation is dispersed in a form and amount effective to swell the polymeric matrix and to provide a defined pattern of release of the agent from the matrix over a period of time between one day and nine months, when the matrix is placed in an aqueous solution. - View Dependent Claims (12, 13, 14)
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Specification