Method of treating neurodegenerative diseases
First Claim
1. A method of treating a Mild Cognitive Impairment in a human consisting essentially of co-administering to said human an effective amount of a cholinesterase inhibitor or a cholenergic receptor agonist and an effective amount of a selective COX-2 inhibitor.
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Accused Products
Abstract
The present invention provides a method of treating a neurodegenerative disease, and in particular Alzheimer'"'"'s disease, Mild Cognitive Impairment or other objective memory impairment which comprises the co-administration of ARICEPT or other cholinesterase inhibitor or cholenergic angonist and an effective amount of a selective COX-2 inhibitor. Although a wide range of COX-2 inhibitors may be employed in combination with ARICEPT, there are preferred choices which are specifically set forth herein.
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Citations
13 Claims
- 1. A method of treating a Mild Cognitive Impairment in a human consisting essentially of co-administering to said human an effective amount of a cholinesterase inhibitor or a cholenergic receptor agonist and an effective amount of a selective COX-2 inhibitor.
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3. A method of treating a Mild Cognitive Impairment in a human consisting essentially of co-administering to said human 5 or 10 mg of ARECEPT, once or twice a day and an effective amount of a selective COX-2 inhibitor.
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4. A method of treating a Mild Cognitive Impairment in a human consisting essentially of co-administering to said human an effective amount of a cholinesterase inhibitor or a cholenergic agonist and 5 to 400 mg of a selective COX-2 inhibitor once or twice a day.
- 6. A method of treating Alzheimer'"'"'s disease in a human consisting essentially of co-administering to said human an effective amount of a cholinesterase inhibitor or a cholenergic receptor agonist and an effective amount of a selective COX-2 inhibitor.
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8. A method of treating Alzheimer'"'"'s disease in a human consisting essentially of co-administering to said human 5 or 10 mg of ARECEPT, once or twice a day and an effective amount of a selective COX-2 inhibitor.
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10. A method of treating a Mild Cognitive Impairment in a human consisting essentially of co-administering to said human 5 or 10 mg of ARECEPT, once or twice a day and 5 to 400 mg of a selective COX-2 inhibitor once or twice a day.
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11. A method of treating Alzheimer'"'"'s disease in a human consisting essentially of co-administering to said human 5 or 10 mg of ARECEPT, once or twice a day and 5 to 400 mg of a selective COX-2 inhibitor once or twice a day.
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12. A pharmaceutical compositions for treating Mild Cognitive Impairment, consisting essentially of a pharmaceutically acceptable carrier and a non-toxic therapeutically effective amount of ARICEPT and an effective amount of a selective COX-2 inhibitor.
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13. A pharmaceutical compositions for treating Alzheimer'"'"'s Disease, consisting essentially of a pharmaceutically acceptable carrier and a non-toxic therapeutically effective amount of ARICEPT and an effective amount of a selective COX-2 inhibitor compound.
Specification