Method of making biocompatible polymeric adsorbing material for purification of physiological fluids of organism

• US 6,531,523 B1
• Filed: 10/10/2000
• Issued: 03/11/2003
• Est. Priority Date: 10/10/2000
• Status: Active Grant

• Current Assignee: Cytosorbents Corporation
• Original Assignee: RenalTech International LLC
• Inventors: Davankov, Vadim, Pavlova, Ludmila, Tsyurupa, Maria
• Primary Examiner(s): Zalukaeva, Tatyana
• Application Number:
  US09/684,085
• Time in Patent Office: 882 Days
• Field of Search: 525/333.2, 525/244, 525/246, 525/260, 525/263, 525/267, 525/242, 525/243, 521/65, 521/69, 521/72, 523/201, 523/206, 526/73, 526/319
• US Class Current: 523/201
• CPC Class Codes: B01J 20/26 Synthetic macromolecular compounds
• CPC Class Codes: B01J 20/261 obtained by reactions only involving carbon to carbon unsaturated bonds macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds per se C08F
• CPC Class Codes: B01J 20/264 derived from different types of monomers, e.g. linear or branched copolymers, block copolymers, graft copolymers
• CPC Class Codes: B01J 20/267 Cross-linked polymers
• CPC Class Codes: B01J 20/28019 Spherical, ellipsoidal or cylindrical
• CPC Class Codes: B01J 20/28057 Surface area, e.g. B.E.T specific surface area
• CPC Class Codes: B01J 20/28078 Pore diameter
• CPC Class Codes: B01J 20/3064 Addition of pore forming agents, e.g. pore inducing or porogenic agents
• CPC Class Codes: B01J 20/321 consisting of a polymer obtained by reactions involving only carbon to carbon unsaturated bonds
• CPC Class Codes: B01J 20/327 Polymers obtained by reactions involving only carbon to carbon unsaturated bonds
• CPC Class Codes: B01J 20/3276 Copolymers
• CPC Class Codes: B01J 20/3278 Polymers being grafted on the carrier
• CPC Class Codes: B01J 20/3282 Crosslinked polymers
• CPC Class Codes: B01J 20/3293 Coatings on a core, the core being particle or fiber shaped, e.g. encapsulated particles, coated fibers
• CPC Class Codes: C08F 257/02 on to polymers of styrene or alkyl-substituted styrenes
• CPC Class Codes: C08F 265/04 on to polymers of esters
• CPC Class Codes: C08F 271/00 Macromolecular compounds obtained by polymerising monomers on to polymers of nitrogen-containing monomers as defined in group C08F26/00
• CPC Class Codes: C08J 2201/05 Elimination by evaporation or heat degradation of a liquid phase
• CPC Class Codes: C08J 9/286 the liquid phase being a solvent for the monomers but not for the resulting macromolecular composition, i.e. macroporous or macroreticular polymers

Abstract

A beaded polymeric adsorbent has a core part; a shell part arranged around the core part, with one of the parts having a lipophilic property and another of the parts having a hydrophilic property, and is produced by preparing an organic phase composed of water insoluble monounsaturated and poly unsaturated comonomers; preparing an aqueous phase composed of a mixture of water soluble monounsaturated and polyunsaturated comonomers; forming a dispersion of the organic phase and the aqueous phase in a single vessel; and creating conditions for first polymerizing of one of the phases which forms the core part and thereafter polymerizing the other of the phases which forms the shell part.

Claims

1. A method of producing beaded polymer porous adsorbents having a hydrophobic porous core part and a hydrophilic shell part, comprising the steps of preparing an organic phase composed of water insoluble monounsaturated and polyunsaturated comonomers and a porogen;

preparing an aqueous phase composed of a mixture of water soluble monounsaturated and polyunsaturated comonomers;

forming a dispersion of the organic phase and the aqueous phase in a single vessel; and

creating conditions for first polymerizing of said organic phase and formation of said hydrophobic porous core part and thereafter polymerizing said aqueous phase and formation of said hydrophilic shell part which coats said core part.

2. A method as defined in claim 1, wherein said creating step includes introducing in said organic phase which forms the core part a radical polymerization initiator.

3. A method as defined in claim 1, wherein said creating step includes introducing in said hydrophilic phase which forms the shell part a suspension stabilizer.

4. A method as defined in claim 1, wherein said organic phase contains a mixture of monovinyl co-monomers selected from group consisting of styrene, α

-methylstyrene, ethylstyrene, vinylbenzylchloride, n-alkyl methacrylate, vinyl chloride, acrylo nitrile and polyvinyl co-monomers selected from the group composed of divinylbenzene, trivinylbenzene, m-diisopropenylbenzene, ethyleneglycol dimethacrylate, divinylether, and mixtures thereof.

5. A method as defined in claim 1, wherein said organic phase contains as the porogen water-immiscible organic solvents selected from the group consisting of non-solvents good solvents and Θ

-solvents for the corresponding polymer that forms in that phase, to form at a macroporous, microporous and mesoporous crosslinked polymeric material, respectively.

6. A method as defined in claim 1, wherein said aqueous phase contains a mixture of water soluble monovinyl co-monomers selected from the group consisting of 2-hydroxyethyl-methacrylate, glicidyl methacrylate, N-vinylpyrrolidone, N-vinylcaprolactame, acrylamide, N-isopropylacrylamide and polyvinyl co-monomers selected from the group consisting of methylene-bis(acrylamide), divinyl sulfone, and mixtures thereof.

7. A method as defined in claim 1, wherein a ratio of said monounsaturated to said polyunsaturated comonomers varies in the range between 0:

100 and 95;

5 for said organic phase and between 100;

0 and 90;

10 for said aqueous phase.

8. A method as defined in claim 1, wherein said mixture of said water soluble mono unsaturated and polyunsaturated co-monomers is added to said aqueous phase at a beginning of a polymerization process in said organic phase.

9. A method as defined in claim 1, wherein said mixture of mono unsaturated and polyunsaturated co-monomers in said aqueous phase is added to said mixture of said mono unsaturated and polyunsaturated co-monomers of said organic phase only after a major part of the co-monomers in said organic phase converts into a polymeric material.