Electrotransort device comprising blades
First Claim
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1. An apparatus for transporting a compound through a barrier membrane of a mammal comprising:
- (a) a vessel having a membrane contacting surface, said surface having a plurality of exposed blades and a channel adjacent to said blades;
(b) a reservoir in communication with said channels for storage of said compound; and
(c) an electrode in communication with said reservoir, wherein the width and the thickness of said blades are tapered away from said surface.
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Abstract
The present invention relates to an apparatus for transporting a compound through a barrier membrane of a mammal comprising: (a) a vessel having a membrane contacting surface, said surface having a plurality of exposed blades and a channel adjacent to said blades; (b) a reservoir in communication with said channels for storage of said compound; and (c) an electrode in communication with said reservoir, wherein the width of said blades are tapered away from said surface.
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Citations
20 Claims
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1. An apparatus for transporting a compound through a barrier membrane of a mammal comprising:
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(a) a vessel having a membrane contacting surface, said surface having a plurality of exposed blades and a channel adjacent to said blades;
(b) a reservoir in communication with said channels for storage of said compound; and
(c) an electrode in communication with said reservoir, wherein the width and the thickness of said blades are tapered away from said surface. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 20)
an electrode reservoir in communication with said electrode;
a compound reservoir in communication with said channels; and
a semipermeable membrane in communication with said electrode reservoir and said compound reservoir.
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12. An apparatus as defined in claim 11, wherein said semipermeable membrane only permeates molecules having a molecular weight less than the molecular weight of said compound.
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13. An apparatus as defined in claim 11, wherein the volume ratio of said compound reservoir to said electrode reservoir is less than about 1.
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14. An apparatus as defined in claim 1, further comprising an electronic control unit electrically connected to said electrode, said electronic control unit for controlling the electrical current through said electrode.
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15. An apparatus as defined in claim 14, further comprising at least one sensor, said sensor transmitting detected information to said electronic control unit, said electronic control unit varying the electrical current through said electrode dependent on the information received from said sensor.
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16. An apparatus as defined in claim 15, wherein said sensor is selected from the group consisting of a pH sensor, conductivity sensor, ion-selective electrode, sensor based on amperometry, and sensor based on potentiometry.
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20. An apparatus as defined in claim 1, wherein said apparatus further comprises a counter electrode and an electronic control unit, wherein said electronic control unit is electrically connected to said electrode and said counter electrode, and said electronic control unit controls the electrical current through said electrode.
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17. A transdermal iontophoretic system comprising:
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(a) a first electrode comprising (1) a vessel having a membrane contacting surface, said membrane contacting surface having a plurality of exposed blades and channels adjacent said blades wherein the width and the thickness of said blades are tapered away from said surface;
(2) a reservoir in communication with said channels; and
(3) an electrode in communication with said reservoir;
(b) a counter electrode; and
(c) an electronic control unit, wherein said electronic control unit is electrically connected to said electrode and said counter electrode, and said electronic control unit controls the electrical current through said electrode.
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18. A method for transporting a compound across a barrier membrane of a mammal comprising:
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(a) penetrating said barrier membrane with a plurality of blades spaced at predetermined intervals to form pathways through said barrier membrane; and
(b) applying an electrical current through said mammal to cause a compound to cross said barrier membrane through said pathways, wherein the width and the thickness of said blades are tapered away from said surface. - View Dependent Claims (19)
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Specification