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Methods for selectively stimulating proliferation of T cells

  • US 6,534,055 B1
  • Filed: 05/04/1995
  • Issued: 03/18/2003
  • Est. Priority Date: 11/23/1988
  • Status: Expired due to Term
First Claim
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1. A method for expanding a population of CD4+ T cells in number of from about 100 to about 100,000 fold over the original CD4+ T cell population or to about 10 log10 to 12 log10, comprising:

  • a) contacting a population of CD4+ T cells with a solid phase surface comprising 1) an anti-CD3 antibody; and

    2) a second agent which stimulates a CD28-associated signal in the T cells selected from a group consisting of an anti-CD28 antibody, B7-1, and B7-2, wherein said anti-CD3 antibody and said second agent are immobilized on the same solid phase surface;

    b) adding exogenous IL-2 to the population of CD4+ T cells, such that the population of CD4+ T cells increase in number from about 100 to about 100,000 fold over the original CD4+ T cell population or to about 10 log10 to 12 log10.

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