Porous tissue scaffoldings for the repair or regeneration of tissue
First Claim
1. A method for the repair or regeneration of tissue comprising contacting cells with a biocompatible gradient foam having a biocompatible gradient foam having a first location and a second location wherein the biocompatible gradient foam has a substantially continuous transition in at least one characteristic selected from the group consisting of composition, stiffness, flexibility, bioabsorption rate and pore architecture from the first location to the second location of said biocompatible gradient foam.
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Abstract
The present patent describes a three-dimensional inter-connected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These foams can be made from a blend of absorbable and biocompatible polymers that are formed into foams having a compositional gradient transitioning from predominately one polymeric material to predominately a second polymeric material. These gradient foams are particularly well suited to tissue engineering applications and can be designed to mimic tissue transition or interface zones.
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Citations
36 Claims
- 1. A method for the repair or regeneration of tissue comprising contacting cells with a biocompatible gradient foam having a biocompatible gradient foam having a first location and a second location wherein the biocompatible gradient foam has a substantially continuous transition in at least one characteristic selected from the group consisting of composition, stiffness, flexibility, bioabsorption rate and pore architecture from the first location to the second location of said biocompatible gradient foam.
- 18. A method for the repair or regeneration of tissue comprising contacting cells with a biocompatible foam having a first surface and a second surface with interconnecting pores and channels.
Specification