Sensor array for rapid materials characterization

• US 6,535,822 B2
• Filed: 05/23/2001
• Issued: 03/18/2003
• Est. Priority Date: 12/11/1998
• Status: Expired due to Fees

• Current Assignee: Freeslate Inc. (Unchained Labs Inc.)
• Original Assignee: James Bennett, Paul Mansky
• Inventors: Bennett, James, Mansky, Paul
• Primary Examiner(s): WACHSMAN, HAL D
• Application Number:
  US09/863,532
• Publication Number:
  US 20020032531A1
• Time in Patent Office: 664 Days
• Field of Search: 702/19, 702/21-24, 702/136, 702/27, 702/28, 702/30-32, 702/57, 702/64, 702/65, 702/113-119, 702/124, 702/126, 702/130, 702/132-134, 702/183, 702/184, 702/189, 702/FOR-105, 702/FOR-115, 702/FOR.134, 702/FOR.135, 702/FOR.142, 702/FOR.143, 702/FOR.170, 702/FOR.171, 700/266, 700/268, 700/269, 700/299, 700/300, 422/70, 422/89, 422/68.1, 422/88, 422/98, 422/30, 422/83, 422/90, 422/82.01, 422/82.12, 422/82.13, 422/82.05, 422/82.02, 422/82.03, 422/82.06, 422/61, 422/66, 422/67, 422/69, 422/81, 422/82.04, 422/76, 422/77, 422/82.11, 422/51, 436/149-151, 436/806, 436/157, 436/43, 435/287.1, 435/287.9, 435/288.7, 374/43, 374/50, 374/36, 374/142, 374/32, 374/31, 374/117, 738/63, 738/630--86, 738/631.1, 738/631.2, 204/400, 204/401, 204/416, 204/406-410, 204/298.11, 205/775, 205/776.5, 205/787, 205/782.5
• US Class Current: 702/21
• CPC Class Codes: B01J 19/0046 Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays synthesis methods per se C40B50/00
• CPC Class Codes: B01J 2219/00605 the compounds being directly bound or immobilised to solid supports
• CPC Class Codes: B01J 2219/00612 the surface being inorganic
• CPC Class Codes: B01J 2219/00621 by physical means, e.g. trenches, raised areas
• CPC Class Codes: B01J 2219/00637 by coating it with another layer
• CPC Class Codes: B01J 2219/00653 the compounds being bound to electrodes embedded in or on the solid supports
• CPC Class Codes: B01J 2219/00659 Two-dimensional arrays
• CPC Class Codes: B01J 2219/00707 separated from the reactor apparatus
• CPC Class Codes: B01J 2219/00745 Inorganic compounds
• CPC Class Codes: B01J 2219/00747 Catalysts
• CPC Class Codes: C40B 30/08 by measuring catalytic activity
• CPC Class Codes: C40B 40/18 Libraries containing only inorganic compounds or inorganic materials
• CPC Class Codes: G01N 25/005 by investigating specific heat
• CPC Class Codes: G01N 25/18 by investigating thermal conductivity by calorimetry G01N25/20; by measuring change of resistance of an electrically-heated body G01N27/18
• CPC Class Codes: G01N 27/72 by investigating magnetic variables

Abstract

A sensor-array based materials characterization apparatus includes a sensor array disposed on a substrate; electronic test circuitry for sending and receiving electrical signals; electronic circuitry for routing signals between selected sensors and the electronic test circuitry; and a computer or processor. Preferably, all or part of the electronic test and signal routing circuitry is contained on the same substrate as the sensor array. Additional circuitry and a processor or computer may be physically separate from the substrate carrying the sensor array, and may be connected to the sensor array substrate. During use, multiple samples are applied to the multiple sensors in the array, and signals are sent to and received from selected sensors. Integration of the electronic test and signal routing circuitry onto the same substrate as the sensor array allows for a high density of sensors on a single substrate, permitting rapid analysis of combinatorial libraries.

Claims

1. An apparatus for characterizing a first material property of a first array of samples and a second material property of a second array of samples, comprising:

a) a first array of 5 or more sensors wherein each sensor of said first array of 5 or more sensors is configured to be associated with at least one sample of said first array of samples;

b) a second array of 5 or more sensors interchangeable with said first array of 5 or more sensors wherein each sensor in said second array of 5 or more sensors is configured to be associated with at least one sample of said second array of samples;

c) electronic test circuitry interchangeably in electrical communication with said first array of 5 or more sensors and said second array of 5 or more sensors through at least one electrical interconnection device wherein said electronic test circuitry is configured for sending an output signal to said first array of samples and said second array of samples respectively through said first array of 5 or more sensors and said second array of 5 or more sensors and said electronic test circuitry is further configured for receiving input signals from said first array of samples and said second array of samples, wherein;

i) said first material property of said first array of samples is determined by comparing said output signals sent to said first array of 5 or more sensors with said input signals from said first array of samples; and

ii) said second material property of said second array of samples is determined by comparing said output signals sent to said second array of 5 or more sensors with said input signals from said second array of samples.

2. The apparatus as in claim 1, wherein said at least one electrical interconnection device includes a multiplexer.

3. The apparatus as in claim 1, wherein said first array of 5 or more sensors are located on a single substrate.

4. The apparatus as in claim 3, wherein said single substrate is at least partially formed of a polymer sheet and wherein a plurality of thermometers are disposed on said polymer sheet for monitoring temperature of said first array of samples.

5. The apparatus as in claim 4, wherein said polymer sheet is at least partially formed of a polyimide.

6. The apparatus as in claim 4 wherein said single substrate includes a heater disposed on a bottom surface of said single substrate.

7. The apparatus as in claim 1, wherein said first material property is selected from the group consisting of heat capacity, specific heat, thermal conductivity and thermal stability.

8. The apparatus as in claim 1, wherein said electronic test circuitry is configured for characterizing said first material property of said first array of samples substantially simultaneously.

9. The apparatus as in claim 1, wherein said electronic test circuitry is configured for characterizing said first material property of said first array of samples in rapid serial succession.

10. The apparatus as in claim 1, further comprising a probe that is selectively positioned over said first array of 5 or more sensors for assisting in sending an output signal to said first array of samples.

11. The apparatus as in claim 1, wherein said first array of samples includes a first 5 samples and said second array of samples includes a second 5 samples wherein said first 5 samples of said first array of samples is substantially the same as said second 5 samples of said second array of samples.

12. The apparatus as in claim 11, wherein said first material property is selected from the group consisting of heat capacity, specific heat, thermal conductivity and thermal stability.

13. The apparatus as in claim 11, wherein said electronic test circuitry is configured for characterizing said first material property of said first array of samples substantially simultaneously.

14. The apparatus as in claim 11, wherein said electronic test circuitry is configured for characterizing said first material property of said first array of samples in rapid serial succession.

15. The apparatus of claim 1 wherein said each sensor of said first array of 5 or more sensors includes interdigitated electrodes.

16. The apparatus of claim 1 wherein said each sensor of said first array of 5 or more sensors conducts a dielectric constant measurement and a thermal measurement simultaneously.

17. The apparatus of claim 1 wherein the first material property is an electrical transport property.