Fluid delivery device with electrically activated energy source

• US 6,537,250 B1
• Filed: 08/24/2000
• Issued: 03/25/2003
• Est. Priority Date: 08/27/1997
• Status: Expired due to Fees

• Current Assignee: Pescadero Beach Holdings Corporation
• Original Assignee: Science Incorporated
• Inventors: Kriesel, Marshall S.
• Primary Examiner(s): NGUYEN, ANH TUAN TUONG
• Application Number:
  US09/645,818
• Time in Patent Office: 943 Days
• Field of Search: 604/131, 604/132, 604/151, 604/153, 604/185, 604/257, 604/259, 604/67, 604/90, 604/890--89, 128/DIG.1
• US Class Current: 604/132
• CPC Class Codes: A61M 2205/36 related to heating or cooling
• CPC Class Codes: A61M 2205/3613 by body heat
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50
• CPC Class Codes: A61M 5/14248 of the skin patch type
• CPC Class Codes: A61M 5/14586 pressurised by means of a flexible diaphragm
• CPC Class Codes: Y10S 128/12 Pressure infusion

Abstract

An implantable delivery apparatus for infusing medicinal fluids into a patient that includes a novel electroresponsive polymer gel material that, upon being stimulated by an electrical field, uniquely functions as an internal energy source for expelling the medicinal fields from the device.

Claims

1. A device for infusing medicinal fluid into a patient at a controlled rate comprising:

(a) a housing having an outlet;

(b) a fluid reservoir containing a fluid disposed within said housing, said fluid reservoir having an inlet and an outlet in communication with said outlet of said housing;

(c) an expandable mass disposed within said housing proximate said reservoir, said expandable mass comprising a semi-solid, which will respond to a change in electric field in a manner to act upon said fluid within said reservoir to cause said fluid to flow outwardly of said outlet of said reservoir; and

(d) control means operably associated with said expandable mass for changing the electric field acting upon said expandable mass.

2. The device as defined in claim 1 in which said mass is disposed within a first expandable structure disposed within said housing.

3. The device as defined in claim 1 further including means for forming said reservoir said means comprising a second expandable structure disposed within said housing and operably associated with said first expandable bellows.

4. The device as defined in claim 1 in which said mass comprises a electroresponsive gel.

5. The device as defined in claim 1 further including a cannula connected to said housing and communicating with said reservoir for delivering fluid from said reservoir to the patient.

6. The device as defined in claim 1 further including an ullage disposed within said housing and located proximate said fluid reservoir.

7. The device as defined in claim 1 in which said mass expands upon a change in the electric field acting upon said mass.

8. The device as defined in claim 1 in which said mass contracts upon a change in the electric field acting upon said expandable mass.

9. The device as defined in claim 1 further including fill means in communication with said reservoir for filling said reservoir.

10. The device as defined in claim 9 in which said housing comprises a base and a cover superimposed over said base and in which said fill means comprises a septum disposed within said cover, said septum being pierceable by a cannula inserted into said septum.

18. The device as defined in claim 10 further including sensor means connected to said housing for sensing changes in the patient'"'"'s body.

11. An implantable device for implantation within a patient for infusing medicinal fluid into the patient at a controlled rate comprising:

(a) a housing having an outlet;

(b) a fluid reservoir containing a fluid disposed within said housing, said reservoir having an inlet and an outlet in communication with said outlet of said housing;

(c) an electroresponsive, expandable polymer gel disposed within said housing proximate said reservoir, said polymer gel upon being stimulated by electric current, will expand so as to act upon said fluid within said reservoir to cause said fluid to flow outwardly of said outlet of said reservoir; and

(d) stimulation means for stimulating said polymer gel, said stimulation means comprising a source of electric current.

12. The device as defined in claim 11 in which said polymer gel is contained within an expandable structure disposed within said housing.

13. The device as defined in claim 11 further including a second expandable structure disposed within said housing, said fluid reservoir being formed by said second expandable structure.

14. The device as defined in claim 11 in which source of electric current comprises an electric circuit.

15. The device as defined in claim 11 in which said source of electric current comprises:

(a) a base;

(b) a pair of spaced-apart electrodes connected to said plate; and

(c) a source of electricity connected to said electrodes.

16. The device as defined in claim 11 further including an impedance frit disposed between said fluid reservoir and said outlet of said housing.

17. The device as defined in claim 11 further including a delivery cannula connected to said outlet of said housing for delivery fluid to the patient.

19. The device as defined in claim 11 further including fill means carried by said housing for filling said reservoir.

20. The device as defined in claim 19 in which said fill means comprises a septum carried by said housing, said septum being pierceable by a cannula inserted into said septum.

21. An implantable device for implantation within a patient for infusing medicinal fluid into the patient at a controlled rate comprising:

(a) a housing having an outlet;

(b) a fluid reservoir containing a fluid disposed within said housing, said reservoir having an inlet and an outlet in communication with said outlet of said housing;

(c) an electroresponsive, expandable polymer disposed within said housing proximate said reservoir, said polymer, upon being stimulated, expanding to act upon said fluid within said reservoir to cause said fluid to flow outwardly of said outlet of said reservoir;

(d) stimulation means for stimulating said expandable polymer, said stimulation means comprising a source of electrical current; and

(e) delivery means connected to said outlet of said housing for delivering fluid to the patient.

22. The device as defined in claim 21 in which said polymer gel undergoes a change in polymer conformation upon being stimulated.

23. The delivery devices defined in claim 21 in which said delivery means comprises an elongated cannula having a first end connected to said outlet of said housing and a second end terminating in a porous tip.

24. The device as defined in claim 21 in which said expandable polymer is contained within an expandable structure disposed within said housing.

25. The device as defined in claim 21 further including a second expandable structure disposed within said housing, said fluid reservoir being formed by said second expandable structure.

26. The device as defined in claim 21 further including physiological sensor means connected to said housing for sensing physiological changes in the patient.

27. The device as defined in claim 21 further including fill means carried by said housing for filling said reservoir.

28. The device as defined in claim 27 in which said fill means comprises a septum carried by said housing, said septum being pierceable by a cannula inserted into said septum.