Implant device with a retinoid for improved biocompatibility

• US 6,537,568 B2
• Filed: 10/17/2001
• Issued: 03/25/2003
• Est. Priority Date: 08/11/1997
• Status: Expired due to Fees

• Current Assignee: Allergan Incorporated (Abbvie Incorporated)
• Original Assignee: Allergan Incorporated (Abbvie Incorporated)
• Inventors: Olejnik, Orest, Hughes, Patrick M., Kent, John S.
• Primary Examiner(s): AZPURU, CARLOS A
• Application Number:
  US09/982,219
• Publication Number:
  US 20020022047A1
• Time in Patent Office: 524 Days
• Field of Search: 424/426, 424/422, 424/423, 424/424, 514/725, 514/953, 604/890.1
• US Class Current: 424/423
• CPC Class Codes: A61K 31/07 Retinol compounds, e.g. vitamin A retinoic acids A61K31/203
• CPC Class Codes: A61K 31/192 having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid cannabinoids A61K31/658
• CPC Class Codes: A61K 31/455 Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
• CPC Class Codes: A61K 9/0051 Ocular inserts, ocular implants
• CPC Class Codes: A61L 2300/428 Vitamins, e.g. tocopherol, riboflavin
• CPC Class Codes: A61L 2300/442 Colorants, dyes
• CPC Class Codes: A61L 2300/604 Biodegradation
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

An implant device is provided which incorporates a retinoid for improving the biocompatibility of the device in tissue. The device may be bioerodible for the purpose of systemically or locally releasing a therapeutic agent in tissue or it may be a permanent implant which includes a surface treated with a retinoid for increasing the biocompatibility thereof.

Claims

1. An implantable device comprising;

a surgically implantable hard tissue replacement prosthesis; and

, in combination therewith, retinoid means for improving biocompatibility of the prosthesis.

2. The device according to claim 1 wherein said retinoid means is present in the form of a film on the prosthesis.

3. The device according to claim 2 wherein said retinoid means is bonded to a surface of the prostheses.

4. The device according to claim 1 wherein said retinoid means comprises a naturally occurring retinoid.

5. The device according to claim 1 wherein said retinoid means is selected from a group consisting of Vitamin A, Vitamin A aldehyde, Vitamin A acid and their synthetic and natural congeners.

6. A device according to claim 1 wherein the retinoid comprises p-[(E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl1-2-naphthyl)propenyl]-benzoic acid.

7. The device according to claim 1 wherein the retinoid means is incorporated into the prosthesis for release by the prosthesis in order to improve biocompatibility of the prosthesis.

8. The device according to claim 1 wherein said hard tissue replacement prosthesis comprises a cardiac valve component.

9. The device according to claim 1 wherein said hard tissue replacement prosthesis comprises a joint prosthesis.

10. The device according to claim 9 whereas said hard tissue replacement prosthesis further comprises rigid fixation pins for joining the prosthesis to bone.

11. The device according to claim 1 whereas said hard tissue replacement prosthesis comprises a stud and a pin for joining the prosthesis to bone tissue.