Calcium phosphate artificial bone as osteoconductive and biodegradable bone substitute material

• US 6,537,589 B1
• Filed: 07/25/2000
• Issued: 03/25/2003
• Est. Priority Date: 04/03/2000
• Status: Expired due to Term

• Current Assignee: Kyungwon Medical Co., Ltd.
• Original Assignee: Kyungwon Medical Co., Ltd.
• Inventors: Lee, Ho Yeon, Kim, Hong Yeoul, Chae, Soo Kyung, Lee, Chang Hun, Seo, Kang Moon
• Primary Examiner(s): Dees, Jose′ G.
• Assistant Examiner(s): CHOI, FRANK I
• Application Number:
  US09/624,794
• Time in Patent Office: 973 Days
• Field of Search: 424/422, 424/423, 424/426, 424/601, 424/602, 424/604, 424/606, 424/682, 424/696, 424/709, 424/722
• US Class Current: 424/602
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2/4644 Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material bone material A61F2/28; disintegrating or milling devices B02C
• CPC Class Codes: A61F 2002/30062 (bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
• CPC Class Codes: A61F 2002/4648 Means for culturing bone graft
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61F 2310/00293 containing a phosphorus-containing compound, e.g. apatite
• CPC Class Codes: A61L 24/02 containing inorganic materials
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: A61L 27/12 Phosphorus-containing materials, e.g. apatite
• CPC Class Codes: A61P 19/00 Drugs for skeletal disorders
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 19/10 for osteoporosis

Abstract

An artificial bone promotive of osteoanagenesis comprising a calcium phosphate cement and a linear polyphosphate, wherein the calcium phosphate cement comprises β-tricalcium phosphate, monocalcium phosphate, calcium sulfate hemihydrate and other additives. The artificial bone is non-toxic to the body chemically stable, and has an excellent biodegradability. The artificial bone may be applied as substitutes for bone cements, allografts and autografts.

Claims

1. A calcium phosphate artificial bone suitable for use in biocompatible bone substitution and osteoanagenesis, comprising a calcium phosphate cement and a polyphosphate, wherein the calcium phosphate cement comprises 50-58 wt. % of β

-tricalcium phosphate, 10-15 wt. % of monocalcium phosphate, 8-12 wt. % of calcium sulfate hemihydrate and 5-20 wt. % of other additives.

2. The calcium phosphate artificial bone according to claim 1, which is osteoconductive and osteoinductive, biodegradable substitute material.

3. The calcium phosphate artificial bone according to claim 1, wherein the polyphosphate has a linear structure.

4. The calcium phosphate artificial bone according to claim 1, wherein the polyphosphate is contained in an amount of 0.001 to 0.05% by weight based on the total weight of the artificial bone.

5. The calcium phosphate artificial bone according to claim 1, wherein the chain length of the polyphosphate is 3-200 orthophosphate molecules.

6. The calcium phosphate artificial bone according to claim 1, wherein the chain length of the polyphosphate is 10-100 orthophosphate molecules.

7. The calcium phosphate artificial bone according to claim 1, wherein the chain length of the polyphosphate is 60-80 orthophosphate molecules.

8. The calcium phosphate artificial bone according to claim 1, wherein the polyphosphate is in a salt form.

9. The calcium phosphate artificial bone according to claim 8, wherein the salt form is selected from the group consisting of sodium salt, potassium salt and calcium salt.

10. The calcium phosphate artificial bone according to claim 1, which is applied for the treatment of defects and fractures in every bone of the body, the cure of osteoporous, the fillers of implant for dental surgery, the bone substitute for plastic surgery, the substitution of defected bones in the operation on joints, including hip-joint, knee-joint and shoulder-joint, and the operation on vertabra.