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Synergistic methods and compositions for treating cancer

  • US 6,537,988 B2
  • Filed: 03/26/2001
  • Issued: 03/25/2003
  • Est. Priority Date: 03/27/2000
  • Status: Expired due to Fees
First Claim
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1. A method for the treatment of cancer which comprises administering to a mammalian specie in need thereof a synergistically, therapeutically effective amount of (1) at least one agent selected from the group consisting of anti-proliferative cytotoxic agents and cytostatic agents and (2) a compound of formula I embedded imageor a pharmaceutically acceptable salt thereof whereinR1 is Cl, Br, CN, optionally substituted phenyl, or optionally substituted 2-,3- or 4-pyridyl;

  • R2 is optionally substituted lower alkyl, or optionally substituted aralkyl;

    R3 and R5 are each independently optionally substituted lower alkyl, optionally substituted aryl, or optionally substituted heterocyclo;

    R4 is hydrogen or lower alkyl;

    Z1 is CO, SO2, CO2 or SO2N(R5)—

    ; and

    n is 1 or 2;

    provided that the cytotoxic agent and/or cytostatic agent is administered simultaneously with or prior to the formula I compound.

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