Compositions and methods relating to DNA mismatch repair genes
First Claim
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1. A composition comprising purified antibodies that bind specifically to the hMLH1 protein as shown in SEQ ID NO:
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Abstract
Genomic sequences of human mismatch repair genes and gene products are described, as are methods of detecting mutations and/or polymorphisms in those genes. Also described are methods of diagnosing cancer susceptibility in a subject, and methods of identifying and classifying mismatch-repair-defective tumors. In particular, sequences and methods relating to human mutL homologs, hMLH1 and hPMS1 genes and gene products are provided.
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6 Claims
- 1. A composition comprising purified antibodies that bind specifically to the hMLH1 protein as shown in SEQ ID NO:
Specification