Medical device having wet lubricity and method for its production

• US 6,540,698 B1
• Filed: 11/17/2000
• Issued: 04/01/2003
• Est. Priority Date: 11/19/1999
• Status: Expired due to Term

• Current Assignee: Terumo Kabushiki Kaisha
• Original Assignee: Terumo Kabushiki Kaisha
• Inventors: Ishii, Naoki
• Primary Examiner(s): Hindenburg, Max F.
• Assistant Examiner(s): MARMOR II, CHARLES ALAN
• Application Number:
  US09/714,102
• Time in Patent Office: 865 Days
• Field of Search: 600/433-435, 600/585, 128/897, 128/898, 604/93.01, 604/96.01, 604/164.1, 604/164.11, 604/264, 604/265, 604/523, 623/1--, 623/3.1, 523/105, 523/106, 523/112, 523/113, 523/201, 427/2.1, 427/2.24, 427/2.25, 427/402, 427/407.1, 427/412.1, 424/422, 424/423, 424/429, 428/36.91, 428/420-424, 528/904
• US Class Current: 600/585
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 31/10 Macromolecular materials

Abstract

A highly safe medical device which exhibits long-lasting low surface friction in a body fluid or in an aqueous medium is provided. Also provided is a method for producing such medical device wherein substantially no limitation is imposed on the type of the substrate used, and the hydrophilic high molecular weight compound or the water-soluble or water-swellable high molecular weight compound responsible for the surface lubricity can be readily coated on the surface. In the present invention, a hydrophilic high molecular weight compound having at least one carbonyl group or hydrazine residue in the molecule and a cross-linking agent having at least two hydrazine residues or carbonyl groups in the molecule are reacted to thereby form a surface lubrication layer comprising the reaction product. In another embodiment, an interpenetrating network is formed between the reaction product of a compound having at least one carbonyl group or hydrazine residue in the molecule and a cross-linking agent, and a water-soluble or water-swellable high molecular weight compound to thereby form a surface lubrication layer.

Claims

1. A medical device having a surface exhibiting lubricity with wet wherein the medical device has a surface lubrication layer formed on the substrate constituting the medical device, and said surface lubrication layer comprises a reaction product of a hydrophilic high molecular weight compound having at least one selected from a group consisting a carbonyl group and a hydrazine residue in the molecule and a cross-linking agent having at least two carbonyl groups or hydrazine residues which are capable of reacting with the carbonyl group or the hydrazine residue in one molecule.

2. The medical device according to claim 1 wherein said hydrophilic high molecular weight compound has at least one carbonyl group in the molecule and the cross-linking agent has at least two hydrazine residues in one molecule.

3. The medical device according to claim 1 wherein said surface lubrication layer further comprises a water-soluble or water-swellable high molecular substance.

4. The medical device according to claim 1 wherein said cross-linking agent is soluble in an aqueous solvent.

5. The medical device according to claim 1 wherein said surface lubrication layer further comprises a water-soluble physiologically active substance.

6. A medical device having a surface exhibiting lubricity with wet wherein the medical device has a surface lubrication layer formed on the substrate constituting the medical device, and said surface lubrication layer has an interpenetrating network comprising a reaction product of a carbonyl group-containing compound having at least one carbonyl group in the molecule with a hydrazide compound having at least two hydrazine residues in one molecule and a water-soluble or water-swellable high molecular weight substance.

7. A medical device having a surface exhibiting lubricity with wet wherein the medical device has a surface lubrication layer formed on the substrate constituting the medical device, and said surface lubrication layer has an interpenetrating network comprising a reaction product of a hydrazide compound having at least one hydrazine residue in the molecule with a carbonyl group-containing compound having at least two carbonyl groups in one molecule and a water-soluble or water-swellable high molecular weight substance.

8. A method for producing a medical device having a surface exhibiting lubricity with wet comprising the steps of:

coating the surface of the substrate constituting the medical device with a solution containing a hydrophilic high molecular weight compound having at least one carbonyl group in the molecule, and

coating the surface with a solution containing a cross-linking agent comprising a hydrazide compound having at least two hydrazine residues in one molecule.

9. The method for producing a medical device according to claim 8 wherein at least one of said solution containing the hydrophilic high molecular weight compound and said solution containing the cross-linking agent further comprises a water-soluble or water-swellable high molecular weight substance.

10. The method for producing a medical device according to claim 8 wherein an aqueous solvent is used for the solvent of said cross-linking agent.

11. The method for producing a medical device according to claim 10 wherein said solution of said cross-linking agent in said aqueous solvent further comprises a water-soluble physiologically active substance.

12. A method for producing a medical device having a surface exhibiting lubricity with wet comprising the steps of:

coating the surface of the substrate constituting the medical device with a solution containing a hydrophilic high molecular weight compound having at least one hydrazine residue in the molecule, and

coating the surface with a solution containing a cross-linking agent comprising a carbonyl group-containing compound having at least two carbonyl groups in one molecule.

13. The method for producing a medical device according to claim 12 wherein at least one of said solution containing the hydrophilic high molecular weight compound and said solution containing the cross-linking agent further comprises a water-soluble or water-swellable high molecular weight substance.

14. The method for producing a medical device according to claim 12 wherein an aqueous solvent is used for the solvent of said cross-linking agent.

15. The method for producing a medical device according to claim 14 wherein said solution of said cross-linking agent in said aqueous solvent further comprises a water-soluble physiologically active substance.

16. A method for producing a medical device having a surface exhibiting lubricity with wet comprising the steps of:

coating the surface of the substrate constituting the medical device with a solution containing a carbonyl group-containing compound having at least one carbonyl group in the molecule, and

coating the surface with a solution containing a hydrazide compound having at least two hydrazine residues in one molecule;

wherein at least one of said solution containing the carbonyl group-containing compound and said solution containing the hydrazide compound further comprises a water-soluble or water-swellable high molecular substance.

17. A method for producing a medical device having a surface exhibiting lubricity with wet comprising the steps of:

coating the surface of the substrate constituting the medical device with a solution containing a hydrazide compound having at least one hydrazine residue in the molecule, and

coating the surface with a solution containing a cross-linking agent comprising a carbonyl group-containing compound having at least two carbonyl groups in one molecule;

wherein at least one of said solution containing the carbonyl group-containing compound and said solution containing the hydrazide compound further comprises a water-soluble or water-swellable high molecular substance.