Detection of target analytes using particles and electrodes
First Claim
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1. A colloid particle comprisingt at least one covalently attached electron transfer moiety (ETM).
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Abstract
The invention relates to the use of particles comprising binding ligands and electron transfer moieties (ETMs). Upon binding of a target analyte, a particle and a reporter composition are associated and transported to an electrode surface. The ETMs are then detected, allowing the presence or absence of the target analyte to be determined.
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Citations
13 Claims
- 1. A colloid particle comprisingt at least one covalently attached electron transfer moiety (ETM).
- 4. A colloid particle comprising a covalently attached conductive oligomer.
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6. A colloid particle comprising:
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a) a SAM;
b) a capture probe;
c) an amplification sequence; and
d) a label probe hybridized to said amplification sequence, wherein said label probe comprises at least one covalently attached ETM.
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8. A colloid particle comprising:
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a) at least one ETM;
b) a self-assembled monolayer (SAM); and
c) at least one covalently attached nucleic acid.
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9. A colloid particle comprising:
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a) a SAM;
b) a first nucleic acid;
c) a second nucleic acid; and
d) a label probe hybridized to said first nucleic acid, wherein said label probe comprises at least one covalently attached ETM.
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Specification