Stable oil-in-glycerin emulsion

• US 6,544,530 B1
• Filed: 01/22/2001
• Issued: 04/08/2003
• Est. Priority Date: 03/22/1999
• Status: Expired due to Fees

• Current Assignee: J.P.M.E.D. Ltd.
• Original Assignee: J.P.M.E.D. Ltd.
• Inventors: Friedman, Doron
• Primary Examiner(s): Tate, Christopher R.
• Assistant Examiner(s): WINSTON, RANDALL O
• Application Number:
  US09/700,862
• Time in Patent Office: 806 Days
• Field of Search: 424/725, 424/400, 424/405, 424/434, 514/886, 514/937
• US Class Current: 424/400
• CPC Class Codes: A61K 47/10 Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• CPC Class Codes: A61K 47/44 Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin synthetic glycerides, e.g. medium-chain triglycerides, A61K47/14
• CPC Class Codes: A61K 8/06 Emulsions
• CPC Class Codes: A61K 8/922 of vegetable origin
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/0031 Rectum, anus
• CPC Class Codes: A61K 9/0034 Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
• CPC Class Codes: A61K 9/107 Emulsions ; Emulsion preconcentrates; Micelles composition of emulsions A61K47/00
• CPC Class Codes: A61K 9/4858 Organic compounds
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 31/12 Antivirals
• CPC Class Codes: A61P 33/00 Antiparasitic agents
• CPC Class Codes: A61P 37/02 Immunomodulators
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
• CPC Class Codes: A61Q 17/02 containing insect repellants
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/001 Preparations for care of the lips
• CPC Class Codes: A61Q 5/00 Preparations for care of the hair
• CPC Class Codes: B82Y 5/00 : Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

The invention provides a composition of matter comprising a stable oil-in-glycerin emulstion containing at least one oil, at least one emulsifier and glycerin.

Claims

1. A topically applicable stable oil-in-glycerin composition comprising a continuous glycerin phase, at least one vegetable oil, at least one biodegradable emulsifier and at least one bioactive essential oil component for topical, external use on skin and mucosal surfaces wherein the bioactivity of said essential oil is selected from the group consisting of topical anti-inflammatory activity, topical anti-fungal activity, topical anti-bacterial activity, topical anti-parasitic activity, and topical anti-viral activity, and wherein said essential oil is a volatile mixture of esters, aldehydes, alcohols, ketones, and terpenes.

2. A topically applicable stable oil-in-glycerin composition according to claim 1, wherein said emulsifier of vegetable origin is made by condensation of at least one vegetable fatty acid and a vegetable saccharide or disaccharide or poly-saccharide.

3. A topically applicable stable oil-in-glycerin emulsion composition according to claim 1, wherein said emulsion is substantially alcohol free.

4. A topically applicable stable oil-in-glycerin emulsion composition according to claim 1, wherein said glycerin constitutes a continuous phase of said emulsion and a minor portion of water is included in said glycerin phase.

5. A topically applicable stable oil-in-glycerin emulsion composition according to claim 1, wherein said vegetable oil is jojoba oil.

6. A topically applicable stable oil-in-glycerin emulsion composition according to claim 1, wherein said vegetable oil is a vegetable tryglyceride.

7. A topically applicable stable oil-in-glycerin emulsion composition according to claim 6, wherein said vegetable tryglyceride is a medium chain tryglyceride.

8. A topically applicable stable oil-in-glycerin emulsion composition according to claim 7, wherein said medium chain tryglyceride is a capric-caprylic tryglyceride.

9. A topically applicable stable oil-in-glycerin emulsion composition according to claim 8, wherein said capric-caprylic tryglyceride is fractionated coconut oil.

10. A topically applicable stable oil-in-glycerin emulsion composition according to claim 1, wherein said oil is present in an amount ranging from about 0.1-40 wt/wt %.

11. A topically applicable stable oil-in-glycerin emulsion composition according to claim 1, wherein said oil is present in an amount ranging from about 2-20 wt/wt %.

12. A topically applicable stable oil-in-glycerin emulsion composition according to claim 1, wherein said emulsifier is present in an amount ranging from about 0.1-20 wt/wt %.

13. A topically applicable stable oil-in-glycerin emulsion composition according to claim 1, wherein said emulsifier is present in an amount ranging from about 0.1-5 wt/wt %.

14. A topically applicable stable oil-in-glycerin emulsion composition according to claim 2, wherein said bioactive essential oil component is present in an amount ranging from about 0.1-20 wt/wt %.

15. A topically applicable stable oil-in-glycerin emulsion composition according to claim 1, wherein said emulsifier is substantially free of polyoxyethylene.

16. A topically applicable stable oil-in-glycerin emulsion composition according to claim 1, wherein said bioactive essential oil component has low water solubility.

17. A topically applicable stable oil-in-glycerin emulsion composition according to claim 1, for use in oral care.

18. A topically applicable stable oil-in-glycerin emulsion composition according to claim 1, for use in vaginal hygiene.

19. A topically applicable stable oil-in-glycerin emulsion composition according to claim 1, for veterinary use.

20. A topically applicable stable oil-in-glycerin composition comprising a continuous glycerin phase, at least one vegetable oil, at least one biodegradable emulsifier of vegetable origin made by condensation of at least one fatty acid with a vegetable carbohydrate or polycarbohydrate and at least one bioactive essential oil component for topical, external use on skin and mucosal surfaces wherein the bioactivity of said essential oil is selected from the group consisting of topical anti-inflammatory activity, topical anti-fungal activity, topical anti-bacterial activity, topical anti-parasitic activity, and topical anti-viral activity, and wherein said essential oil is a volatile mixture of esters, aldehydes, alcohols, ketones, and terpenes.