Substituted porphyrins
First Claim
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1. A compound of Formula I or II or, when said compound bears a charge, a pharmaceutically acceptable salt thereof, whereinR1 and R3 are the same and are:
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R2 and R4 are the same and are;
Y is halogen or —
CO2X, and each X is the same or different and is an alkyl and each R5 is the same or different and is H or alkyl, and M is a metal selected from the group consisting of zinc, iron, nickel, cobalt, copper and manganese. wherein when R1 and R3 are —
H, R2 and R4 are not orwhen R1 and R3 are —
H, and R2 and R4 are said compound is of Formula II and M is a metal selected from the group consisting of manganese, iron, copper, cobalt and nickel.
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Abstract
The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
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Citations
11 Claims
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1. A compound of Formula I or II
or, when said compound bears a charge, a pharmaceutically acceptable salt thereof, wherein R1 and R3 are the same and are: -
R2 and R4 are the same and are;
Y is halogen or —
CO2X, andeach X is the same or different and is an alkyl and each R5 is the same or different and is H or alkyl, and M is a metal selected from the group consisting of zinc, iron, nickel, cobalt, copper and manganese. wherein when R1 and R3 are —
H, R2 and R4 are notor when R1 and R3 are —
H, and R2 and R4 aresaid compound is of Formula II and M is a metal selected from the group consisting of manganese, iron, copper, cobalt and nickel. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
R2 and R4 are the same and are;
Y is —
F or —
CO2X, andX is the same or different and is a C1-4 alkyl and each R5 is the same or different and is H or C1-4 alkyl.
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3. The compound according to claim 2 wherein X is methyl or ethyl.
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4. The compound according to claim 1 wherein R1, R2, R3 and R4 are the same.
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5. The compound according to claim 1 wherein R1, R2, R3 and R4 are
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6. The compound according to claim 5 wherein X is methyl or ethyl.
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7. The compound according to claim 5 wherein R1, R2, R3 and R4 are the same.
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8. The compound according to claim 7 wherein R1, R2, R3 and R4 are
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9. The compound according to claim 1 wherein said compound is of Formula II.
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10. The compound according to claim 9 wherein M is manganese.
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11. A composition comprising the compound of claim 1 and a carrier.
Specification