Method and apparatus for determining response thresholds

• US 6,547,746 B1
• Filed: 08/27/2001
• Issued: 04/15/2003
• Est. Priority Date: 08/27/2001
• Status: Active Grant

• Current Assignee: Board of Supervisors of Louisiana State University Agricultural & Mechanical College (Louisiana State University System)
• Original Assignee: Board of Supervisors of Louisiana State University Agricultural & Mechanical College (Louisiana State University System)
• Inventors: Marino, Andrew A.
• Primary Examiner(s): Hindenburg, Max F.
• Assistant Examiner(s): Natnithithadha, Navin
• Application Number:
  US09/940,696
• Time in Patent Office: 596 Days
• Field of Search: 600/545, 600/544, 600/546, 600/554, 600/555, 600/558, 600/559, 600/300
• US Class Current: 600/554
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/377 using evoked responses
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives
• CPC Class Codes: A61B 5/726 using Wavelet transforms

Abstract

A method and apparatus for evaluating the response of a biological or nonbiological system to an external or internal stimulus (optical, thermal, auditory, tactile, taste, electrical, magnetic, chemical, biochemical, pharmacological, hormonal, internal cellular transformations, etc.). The system is exposed to the stimulus while at least one electrophysiological signal is recorded. The recorded data is digitized, stored, and analyzed using RQA or other suitable techniques to ascertain the properties of the system'"'"'s response to the stimulus.

Claims

1. A method for evaluating the effects of a stimulus on a system, said method comprising the steps of:

while said system is exposed to a stimulus, monitoring at least one time-dependent output signal of said system;

recording said output signal;

digitizing said recorded signal;

applying a unitary transformation to said digitized signal;

transforming said digitized signal to the time domain;

unfolding said transformed signal in phase space;

applying a filter to said unfolded signal; and

deriving from said filtered signal at least one quantifier characterizing a deterministic structure of said signal.

2. The method as recited in claim 1, further comprising the step of filtering said digitized signal.

3. The method as recited in claim 2, further comprising the step of filtering said digitized signal with a numerical filter.

4. The method as recited in claim 1, wherein said unitary transformation is an amplitude or frequency transformation.

5. The method as recited in claim 1, further comprising the step of integrating or differentiating said recorded signal.

6. The method as recited in claim 1, further comprising the step of rejecting artifacts in said recorded signal.

7. The method as recited in claim 1, wherein said unfolding step is carried out using a selected time delay in a phase space having at least three dimensions.

8. The method as recited in claim 1, further comprising the step of deriving a recurrence diagram for determining said structure.

9. The method as recited in claim 1, wherein said at least one quantifier further comprises a univariate measure selected from the group consisting of percent recurrence, percent determinism, entropy, ratio, trend, correlation dimension, Lyapunov exponent, entropy, and mutual information.

10. The method as recited in claim 1, further comprising the steps of:

processing at least one control output signal of said system according to claim 1; and

comparing at least one quantifier characterizing said control signal to said at least one quantifier characterizing said unfolded signal.

11. The method as recited in claim 1, wherein said output signal corresponds to a physiological parameter, further comprising the next step of analyzing said at least one quantifier to determine a physiological state of said system.

12. The method as recited in claim 1, wherein said output signal is generated in response to a controlled input or an uncontrolled input.

13. The method as recited in claim 1, wherein said stimulus is selected from the group consisting of mechanical., electrical, electromagnetic, magnetic, thermal, hormonal, metabolic, biochemical, pharmacological, sensory, and cellular changes, and combinations thereof.

14. The method as recited in claim 1, wherein said deriving step further comprises an iterative process, said process resulting in further unfolding of said signal in phase space.

15. A method for evaluating the effects of a stimulus on a system, said method comprising the steps of:

while said system is exposed to a stimulus, monitoring at least one output signal of said system;

recording said output signal;

digitizing said recorded signal;

preprocessing said recorded signal,

applying a phase-space filter to said preprocessed signal; and

deriving from said filtered signal at least one quantifier characterizing a deterministic structure of said signal.

16. The method as recited in claim 15, further comprising the step of filtering said digitized signal with a numerical filter.

17. The method as recited in claim 16, further comprising the steps of:

applying a unitary transformation to said digitized signal;

transforming said transformed signal to the time domain, and

unfolding said transformed signal in a phase space having at least three dimensions.

18. The method as recited in claim 15, further comprising the step of suppressing variance in said recorded signal.

19. The method as recited in claim 15, further comprising the step of rejecting artifacts in said recorded signal.

20. The method as recited in claim 15, further comprising the step of deriving a recurrence diagram for determining said structure.

21. The method as recited in claim 15, wherein said at least one quantifier further comprises a univariate measure.

22. The method as recited in claim 15, wherein said output signal is generated in response to a controlled input or an uncontrolled input.

23. The method as recited in claim 15, further comprising the steps of:

processing at least one control output signal of said system according to claim 15; and

comparing said at least one quantifier characterizing said control signal to said at least one quantifier characterizing said unfolded signal.

24. The method as recited in claim 23, wherein said comparing step includes statistically analyzing said quantifiers.

25. An apparatus for evaluating the effects of a stimulus on a system, said apparatus comprising:

means for monitoring at least one time-dependent output signal of said system,

means for digitizing said output signal;

means for preprocessing said digitized signal;

phase-space filter means for removing nonuseful portions of said digitized signal; and

means for generating at least one quantifier characterizing a deterministic structure of said phase-space-filtered signal.

26. The apparatus as recited in claim 25, wherein said preprocessing means further comprises:

means for applying a unitary transformation to said signal;

numerical filter means for filtering said transformed signal; and

means for unfolding said signal in a phase space having at least three dimensions.

27. The apparatus as recited in claim 25, wherein said at least one quantifier is a univariate measure.

28. The apparatus as recited in claim 25, further comprising means for analyzing said at least one quantifier.

29. The apparatus as recited in claim 28, wherein said analyzing means includes means for statistically analyzing said at least one quantifier.

30. The apparatus as recited in claim 25, wherein said system is a physiological system, further comprising means for analyzing said at least one quantifier to determine a physiological state of said system in relation to occurrence and nonoccurrence of said stimulus.