Microfabricated surgical device for interventional procedures

• US 6,547,803 B2
• Filed: 09/20/2001
• Issued: 04/15/2003
• Est. Priority Date: 09/20/2001
• Status: Expired due to Term

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Pisano, Albert P., Seward, Kirk Patrick
• Primary Examiner(s): Reip, David O.
• Assistant Examiner(s): DAVIS, DANIEL J
• Application Number:
  US09/961,080
• Publication Number:
  US 20030055446A1
• Time in Patent Office: 572 Days
• Field of Search: 606/190, 606/191, 606/194, 606/195, 604/272, 604/103.01, 604/103.02, 604/103.07, 604/103.08
• US Class Current: 606/185
• CPC Class Codes: A61B 17/3478 Endoscopic needles, e.g. for infusion biopsy needles A61B10/0233; catheters with injection needles A61M25/0067
• CPC Class Codes: A61B 2017/00247 Making holes in the wall of the heart, e.g. laser Myocardial revascularization
• CPC Class Codes: A61B 2017/00345 Micromachines, nanomachines, microsystems
• CPC Class Codes: A61B 2017/00398 using powered actuators, e.g. stepper motors, solenoids
• CPC Class Codes: A61B 2018/00392 Transmyocardial revascularisation
• CPC Class Codes: A61M 2025/009 the needle having a bent tip, i.e. the needle distal tip is angled in relation to the longitudinal axis of the catheter
• CPC Class Codes: A61M 2025/1086 having a special balloon surface topography, e.g. pores, protuberances, spikes or grooves

Abstract

An actuator for an interventional surgical procedure is described. The actuator may include an actuator body having a distal end and a proximal end. A central expandable section is located between the distal end and the proximal end. The expandable section is operable between an unactuated condition in which the expandable section is in a furled state and an actuated condition in which the expandable section is in an unfurled state. A needle is located at the expandable section. The needle is moveable in an approximately perpendicular direction relative to a central longitudinal axis of the actuator body from a position within the actuator body to a position outside of the actuator body.

Claims

1. An actuator for an interventional surgical procedure comprising:

an actuator body having a distal end and a proximal end;

a central expandable section located between the distal end and the proximal end, said expandable section operable between an unactuated condition in which said expandable section is in a furled state and an actuated condition in which said expandable section is in an unfurled state; and

a needle at said expandable section, said needle being movable in an approximately perpendicular direction relative to a central longitudinal axis of said actuator body from a position within said actuator body to a position outside of said actuator body when said expandable section is caused to change from said furled state to said unfurled state.

2. The actuator of claim 1 wherein the proximal end is joined to an end of a catheter.

3. The actuator of claim 2 wherein the distal end is joined to a tip end of the catheter.

4. The actuator of claim 1 wherein said expandable section includes an interior open area and further including a delivery conduit to supply an activating fluid to the open area to cause said expandable section to change from said furled state to said unfurled state.

5. The actuator of claim 1 wherein said expandable section is made from a polymer.

6. The actuator of claim 1 further including a retaining ring located at the distal end and at the proximal end.

7. The actuator of claim 1 wherein the needle includes a tip having an insertion edge or point.

8. The actuator of claim 7 wherein the tip includes an outlet port and further including a fluid pathway for supplying a therapeutic or diagnostic agent to the outlet port.

9. The actuator of claim 8 wherein the therapeutic agent is selected from the group consisting of:

an inorganic pharmacological agent;

an organic pharmacological agent;

a cell with a treatment function including an undifferentiated, partially differentiated, or fully differentiated stem cell, an islet, or a genetically altered cell;

a micro-organism including a virus, a bacteria, a fungi, or a parasite; and

an organic genetic material including a gene, a chromosome, a plasmid, DNA, RNA, mRNA, rRNA, tRNA, synthetic RNA, or synthetic DNA.

10. The actuator of claim 8 wherein diagnostic agent is selected from the group consisting of:

a contrast medium, a radioactive marker, a fluorescent marker, an antibody marker, and an enzyme marker.

11. The actuator of claim 1 wherein the needle is a microfabricated needle.

12. The actuator of claim 1 wherein the needle is a macroneedle.

13. A microfabricated surgical device for an interventional surgical procedure comprising:

a catheter having a distal end for insertion into and manipulation within a body of a vascularized organism and a proximal end for providing a user with control over the manipulation of the distal end of the catheter within the body;

an actuator joined to the distal end of the catheter, said actuator including an actuator body and a needle joined to an expandable section of the actuator body such that said needle is located within said actuator body when said actuator is in an unactuated condition and outside of said actuator body when said actuator is in an actuated condition, said needle being, movable along a path substantially perpendicular to a central longitudinal axis of said actuator body when said actuator changes from the unactuated condition to the actuated condition; and

fluid connections at the distal end of the catheter and a proximal end of said actuator to supply a therapeutic or diagnostic agent to said needle, and to provide an activating fluid to said actuator to cause said actuator to change from the unactuated condition to the actuated condition.

14. The device of claim 13 wherein the catheter is a therapeutic catheter.

15. The device of claim 13 wherein said expandable section is in a furled state when the actuator is in the unactuated condition and in an unfurled state when the actuator is in the actuated condition.

16. The device of claim 15 wherein said expandable section includes an interior open area to which the activating fluid is supplied to cause said expandable section to change from the furled state to the unfurled state.

17. The device of claim 16 wherein when the activating fluid is removed from the interior open area, said expandable section returns to the furled state.

18. The device of claim 13 wherein said expandable section is made from a polymer.

19. The device of claim 13 further including a retaining ring located at opposite ends of the actuator body.

20. An actuator for an interventional surgical procedure comprising:

an actuator body having a distal end and a proximal end;

a central expandable section located between the distal end and the proximal end, said expandable section operable between an unactuated condition in which said expandable section is in a furled state and an actuated condition in which said expandable section is in an unfurled state; and

a plurality needles at said expandable section, said needles being movable in an approximately perpendicular direction relative to a central longitudinal axis of said actuator body from a position within said actuator body to a position outside of said actuator body, when said expandable section is caused to change from said furled state to said unfurled state.

21. The actuator of claim 20 wherein said needles are spaced along a length of said expandable section.

22. The actuator of claim 21 wherein when said expandable section changes from the furled state to the unfurled state, the plurality of needles move at the same time.

23. The actuator of claim 21 wherein when said expandable section changes from the furled state to the unfurled state, at least one of the plurality of needles moves before another one of the plurality of needles.

24. The actuator of claim 20 wherein when said expandable section changes from the furled state to the unfurled state, at least one of the plurality of needles moves in a direction that is different from the direction of movement of another one of the plurality of needles.

25. An actuator for an interventional surgical procedure comprising:

an actuator body having a distal end and a proximal end;

an expandable section located between the distal end and the proximal end, said expandable section operable between a furled state and an unfurled state; and

a needle at said expandable section, said needle being movable from a position within said actuator body to a position outside of said actuator body, when said expandable section is caused to change from said furled state to said unfurled state.

26. The actuator of claim 25 further including a plurality of needles at said expandable section wherein when said expandable section changes from the furled state to the unfurled state, at least one of the needles moves in a direction that is different from the direction of movement of another one of the needles.

27. An actuator for an interventional surgical procedure comprising:

an actuator body having a distal end and a proximal end;

an expandable section located between the distal end and the proximal end, said expandable section operable between a furled state and an unfurled state;

means for causing said expandable section to change from said furled state to said unfurled state; and

a needle at said expandable section, said needle being movable in an approximately perpendicular direction relative to a central longitudinal axis of said actuator body from a position within said actuator body to a position outside of said actuator body when said expandable section is caused to change from said furled state to unfurled state.

28. The actuator of claim 27 further including means for delivering a therapeutic or diagnostic agents to said needle.