Device and method for detecting analytes
First Claim
1. A process for detection of analytes in a measuring solution comprising the steps of:
- providing marker particles for binding specifically to the analytes, the particles having electrical properties which are different from the measuring solution;
arranging an electrode so that an electric field and an electric current are produced in the solution; and
determining changes in the electric current caused by the marker particles, wherein the electrode arrangement produces an inhomogeneous electric field and the marker particles are electrically insulating.
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Abstract
The invention relates to a method for detecting analytes and to a device for carrying out the method, for use for analysis or diagnosis in the fields of chemistry, biochemistry, molecular genetics, food chemistry, biotechnology, the environment and medicine. Marker particles (5) with different electrical properties or a different relative permeability to those of the measuring solution (3) surrounding them are used to detect the analytes (8). The marker particles (5) either bond specifically to the analytes (8) or to a base (2) in competition with the analyte. The analytes (8) are detected by the changes in an electrical field or an electrical current generated by electrodes (2) or in an electrical voltage applied to an electrode or in a magnetic field, said changes being caused by marker particles which have bonded with the analytes or by marker particles which have instead bonded to the base in an electrical field.
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Citations
20 Claims
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1. A process for detection of analytes in a measuring solution comprising the steps of:
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providing marker particles for binding specifically to the analytes, the particles having electrical properties which are different from the measuring solution;
arranging an electrode so that an electric field and an electric current are produced in the solution; and
determining changes in the electric current caused by the marker particles, wherein the electrode arrangement produces an inhomogeneous electric field and the marker particles are electrically insulating. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A device for determination of analytes in a measuring solution, comprising:
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marker particles which specifically bind to the analytes and have electrical properties which are different from the measuring solution;
an electrode for producing an electric field and an electric current in the measuring solution; and
a measuring device for recording the electric current, wherein an inhomogeneous electric field is produced by arrangement of the electrode and the marker particles are electrically insulating. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification