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Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use

  • US 6,548,491 B2
  • Filed: 05/31/2001
  • Issued: 04/15/2003
  • Est. Priority Date: 12/24/1997
  • Status: Expired due to Term
First Claim
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1. A 17-desoxy-1,3,5(10)-estratriene containing the molecular moiety embedded imageat the C-17 position of the estratriene nucleus, wherein:

  • j is an integer in the range of 0 to 5 inclusive;

    p is an integer in the range of 0 to 6;

    R29 and R30 are selected from the group consisting of hydrogen, lower alkyl, and halogenated lower alkyl, or are linked together to form a heterocycloalkyl ring, with the proviso that R29 and R30 are not both hydrogen; and

    L is a five- or six-membered cyclic moiety that may or may not be aromatic, optionally containing 1 to 4 heteroatoms selected from the group consisting of N, O and S and combinations thereof, and optionally substituted with one or more substituents selected from the group consisting of alkyl, alkenyl, alkoxy, halogenated alkyl, alkenyl, and alkoxy, carboxyl, hydroxy, amino, nitro, cyano, and halogen.

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