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System for the prediction, rapid detection, warning, prevention or control of changes in activity states in the brain of a subject

  • US 6,549,804 B1
  • Filed: 06/10/1999
  • Issued: 04/15/2003
  • Est. Priority Date: 01/23/1996
  • Status: Expired due to Term
First Claim
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1. A method of predicting or detecting the occurrence of abnormal activity in the brain of a subject, said method comprising the steps of:

  • (a) receiving into a signal processor input signals indicative of a subject'"'"'s brain activity;

    (b) determining ictal components in said input signals by applying to said input signals a first filter configured to extract and enhance ictal components of said input signals;

    (c) measuring ictal activity in a foreground epoch of said input signals by applying a first order-statistic filter to said ictal components corresponding to said foreground epoch to produce a foreground measure of said ictal activity;

    (d) measuring ictal activity in a background epoch of said input signals by applying a second order-statistic filter to said ictal components corresponding to said background epoch to produce a background measure of said ictal activity, said background epoch occurring before said foreground epoch;

    (e) determining whether a ratio of said foreground measure to said background measure reaches a threshold level, such being indicative of the occurrence of abnormal activity in the brain of a subject; and

    (f) performing steps (a)-(e) while said abnormal activity is occurring before the onset of electroencephalographic waves of said abnormal activity.

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