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Moncyclic L-nucleosides analogs

  • US 6,552,183 B1
  • Filed: 08/07/2000
  • Issued: 04/22/2003
  • Est. Priority Date: 10/16/1996
  • Status: Expired due to Term
First Claim
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1. A compound having a structure according to Formula III:

  • embedded imagewherein;

    X is independently O, S, CH2 and NR, where R is COCH3;

    R′ and

    R″

    are independently selected from the group consisting of H, CN, C(═

    O)NH2, NH2, C(═

    S)NH2, C(═

    NH)NH2.HCl, C(═

    NOH)NH2, C(═

    NH)OMe, a halogen, lower alkyl and a lower alkyl aryl;

    R1 and R4 are independently selected from the group consisting of H, CN, N3, CH2OH, lower alkyl and a lower alkyl amino; and

    R2, R3, R5, R6, R7 and R8 are independently selected from the group consisting of H, OH, CN, N3, a halogen, CH2OH, NH2, OCH3, NHCH3, ONHCH3, SCH3, SPh, alkenyl, lower alkyl, and a lower alkyl amino, with the proviso that when R2

    R3

    H, then each of R7 and R8 is a hydrogen or taken together are a π

    -bond; and

    where in compounds of Formula III, R′

    is carboxamide or CN and R″

    is hydrogen or a halogen;

    R1

    R4

    R5

    R7

    R8 H and R2

    R3

    OH, and X is oxygen.

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