Methods of sealing an injection site

• US 6,554,851 B1
• Filed: 03/08/2000
• Issued: 04/29/2003
• Est. Priority Date: 05/07/1999
• Status: Expired due to Fees

• Current Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Original Assignee: Scimed Life Systems Incorporated (Boston Scientific Corporation)
• Inventors: Gordon, Lucas S., Palasis, Maria
• Primary Examiner(s): Jackson; Gary
• Application Number:
  US09/521,473
• Time in Patent Office: 1,147 Days
• Field of Search: 606/213
• US Class Current: 606/213
• CPC Class Codes: A61B 17/0057 Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect sutures A61B17/04; closing rectum or urethra near body surface A61F2/0009
• CPC Class Codes: A61B 17/3207 Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions A61B17/32037 takes precedence; endoscopic cutting instruments A61B17/320016
• CPC Class Codes: A61B 18/1477 Needle-like probes
• CPC Class Codes: A61B 2017/00247 Making holes in the wall of the heart, e.g. laser Myocardial revascularization
• CPC Class Codes: A61B 2017/22077 with a part piercing the tissue A61B2017/22044 takes precedence
• CPC Class Codes: A61B 2018/00392 Transmyocardial revascularisation
• CPC Class Codes: A61B 2018/1425 Needle
• CPC Class Codes: A61B 2218/002 Irrigation
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61M 25/0084 being one or more injection needles

Abstract

Methods of sealing an injection site of a tissue are provided, where therapeutic agent has been injected into tissue, resulting in increased efficiency or agent uptake. Also provided are methods for delivering therapeutic agent to a tissue, which include injecting a therapeutic agent into a tissue and subsequently sealing the injection site, or engaging an injection device with the tissue for a sufficient period of time that sealing is not necessary to avoid leakage of the therapeutic agent. In one embodiment radio frequency cautery is used to seal the injection site upon needle removal from the tissue. In other embodiments, the injection site is sealed by resistance heating, laser heating or plugging the site with a solid plug or coagulating material at the site.

Claims

1. A method of inhibiting leakage of a therapeutic agent that has been injected into a target tissue comprising:

injecting the therapeutic agent into the target tissue with an injection device;

removing the injection device from the target tissue, wherein a track is created in the tissue upon removal of the injection device; and

applying a coagulating material at the mouth of the track to seal the mouth and to inhibit leakage of the therapeutic agent from the mouth.

2. The method of claim 1, wherein the coagulating material is a polymeric material or a monomeric material that is polymerized into a polymeric material.

3. The method of claim 2, wherein said polymeric material is selected from the group consisting of poly(oxyalkene) polymers and copolymers and blends with poly(alphahydroxy) acids, collagen, elastin, agarose, agar, hyaluronic acid, hyalobiuronic acid, heparin, cellulose, alginate, curdlan, chitin, chitosan, and derivatives thereof, cellulose acetate, carboxymethyl cellulose, hydroxymethyl cellulose, cellulose sulfate sodium salt, ethylcellulose, poly(acrilic acids), poly(acrylates), polyacrylamides, polyvinyl alcohols, polyethylene glycols, ethylene vinyl acetates, and amino containing polymers.

4. The method of claim 1, wherein the coagulating material is a non-polymeric material.

5. The method of claim 4, wherein the non-polymeric material is selected from the group consisting of sterols, cholesteryl esters, C₁₂-C₁₄ fatty acids, C₁₈-C₃, mono-, di- and triacylglyciderides, sucrose fatty acid esters, sorbitan fatty acid esters, C₁₆-C₁₈ fatty alcohols, esters of fatty alcohols, esters of fatty acids, anhydrides of fatty acids, phospholipids, sphingosine, spingomyelins, ceramides, glycosphingolipids, lanolin, lanolin alcohols, and derivatives, combinations, and mixtures thereof.